Abstract：
Covering: up to December 2023Decalin-containing tetramic acid derivatives, especially 3-decalinoyltetramic acids (3-DTAs), are commonly found as fungal secondary metabolites. Numerous biological activities of this class of compounds, such as antibiotic, antiviral, antifungal, antiplasmodial, and antiprotozoal properties, have been the subject of ongoing research. For this reason, these molecules have attracted a lot of interest from the scientific community and various efforts including semi-synthesis, co-culturing with bacteria and biosynthetic gene sequencing have been made to obtain more derivatives. In this review, 3-DTAs are classified into four major groups based on the absolute configuration of the bicyclic decalin ring. Their biosynthetic pathways, various biological activities, and structure-activity relationship are then introduced.
摘要：
涵盖范围：截至2023年12月，含十氢化萘的四胺酸衍生物，特别是3-癸醛酰四胺酸（3-DTA），通常被发现为真菌次生代谢产物。这类化合物的许多生物活性，比如抗生素，抗病毒，抗真菌药,抗疟药,和抗原生动物特性，一直是正在进行的研究的主题。出于这个原因,这些分子引起了科学界的极大兴趣和各种努力，包括半合成，与细菌共培养和生物合成基因测序，以获得更多的衍生物。在这次审查中,基于双环萘烷环的绝对构型,3-DTA被分为四个主要组。他们的生物合成途径，各种生物活动，然后介绍了结构-活性关系。
