Abstract：
UNASSIGNED: Vitamin D deficiency has been associated with higher rates of autoimmune disease, including noninfectious uveitis. This PRISMA-compliant review and meta-analysis aimed to analyze the correlation between noninfectious uveitis and vitamin D levels.
UNASSIGNED: We searched PubMed, Embase, Cochrane, and Web of Science databases for studies, published in English, assessing vitamin D levels in patients diagnosed with noninfectious uveitis. The outcomes of interest were vitamin D deficiency, vitamin D mean level, vitamin D supplementation, and smoking rates. A subgroup analysis of inactive uveitis and active uveitis was performed. The heterogeneity was assessed with Cochrane Q-test and I2 statistics; p > 0.10 and I2 > 50% were considered significant for heterogeneity. Statistical analysis was conducted using Review Manager 5.3.
UNASSIGNED: 9 studies were included in the meta-analysis comprising a total of 10 711 patients, of whom 1,368 were diagnosed with noninfectious uveitis. Patients with noninfectious uveitis had worse results regarding vitamin D deficiency when compared with the control group (OR 0.58; CI 95% 0.44 to 0.77; p = 0.0002; I2 = 61%). Patients with inactive uveitis had better results towards vitamin D deficiency when compared with active uveitis (OR 5.00; CI 95% 2.84 to 8.81; p < 0.001; I2 = 0%).
UNASSIGNED: Our research supports the increasing evidence that associates vitamin D deficiency with noninfectious uveitis and its activity. Further investigation into the efficacy of vitamin D screening and supplementation in reducing the recurrence of uveitis is necessary.
UNASSIGNED: We searched PubMed, Embase, Cochrane, and Web of Science databases for studies, published in English, assessing vitamin D levels in patients diagnosed with noninfectious uveitis. The outcomes of interest were vitamin D deficiency, vitamin D mean level, vitamin D supplementation, and smoking rates. A subgroup analysis of inactive uveitis and active uveitis was performed. The heterogeneity was assessed with Cochrane Q-test and I2 statistics; p > 0.10 and I2 > 50% were considered significant for heterogeneity. Statistical analysis was conducted using Review Manager 5.3.
UNASSIGNED: 9 studies were included in the meta-analysis comprising a total of 10 711 patients, of whom 1,368 were diagnosed with noninfectious uveitis. Patients with noninfectious uveitis had worse results regarding vitamin D deficiency when compared with the control group (OR 0.58; CI 95% 0.44 to 0.77; p = 0.0002; I2 = 61%). Patients with inactive uveitis had better results towards vitamin D deficiency when compared with active uveitis (OR 5.00; CI 95% 2.84 to 8.81; p < 0.001; I2 = 0%).
UNASSIGNED: Our research supports the increasing evidence that associates vitamin D deficiency with noninfectious uveitis and its activity. Further investigation into the efficacy of vitamin D screening and supplementation in reducing the recurrence of uveitis is necessary.
摘要：
■维生素D缺乏与自身免疫性疾病的高发病率有关，包括非感染性葡萄膜炎.这项符合PRISMA的审查和荟萃分析旨在分析非感染性葡萄膜炎与维生素D水平之间的相关性。
■我们搜索了PubMed，Embase,科克伦,和WebofScience数据库进行研究，以英文出版,评估诊断为非感染性葡萄膜炎患者的维生素D水平。感兴趣的结果是维生素D缺乏，维生素D平均水平，补充维生素D,和吸烟率。进行了非活动性葡萄膜炎和活动性葡萄膜炎的亚组分析。用CochraneQ检验和I2统计来评估异质性;p>0.10和I2>50%被认为是异质性的显著。使用ReviewManager5.3进行统计分析。
■9项研究纳入荟萃分析，共10711名患者，其中1,368人被诊断为非感染性葡萄膜炎。与对照组相比，非感染性葡萄膜炎患者在维生素D缺乏方面的结果较差（OR0.58；CI95％0.44至0.77；p=0.0002；I2=61％）。与活动性葡萄膜炎相比，非活动性葡萄膜炎患者对维生素D缺乏的效果更好（OR5.00;CI95％2.84至8.81;p<0.001;I2=0％）。
■我们的研究支持越来越多的证据表明维生素D缺乏与非感染性葡萄膜炎及其活动相关。有必要进一步研究维生素D筛查和补充在减少葡萄膜炎复发方面的功效。
■我们搜索了PubMed，Embase,科克伦,和WebofScience数据库进行研究，以英文出版,评估诊断为非感染性葡萄膜炎患者的维生素D水平。感兴趣的结果是维生素D缺乏，维生素D平均水平，补充维生素D,和吸烟率。进行了非活动性葡萄膜炎和活动性葡萄膜炎的亚组分析。用CochraneQ检验和I2统计来评估异质性;p>0.10和I2>50%被认为是异质性的显著。使用ReviewManager5.3进行统计分析。
■9项研究纳入荟萃分析，共10711名患者，其中1,368人被诊断为非感染性葡萄膜炎。与对照组相比，非感染性葡萄膜炎患者在维生素D缺乏方面的结果较差（OR0.58；CI95％0.44至0.77；p=0.0002；I2=61％）。与活动性葡萄膜炎相比，非活动性葡萄膜炎患者对维生素D缺乏的效果更好（OR5.00;CI95％2.84至8.81;p<0.001;I2=0％）。
■我们的研究支持越来越多的证据表明维生素D缺乏与非感染性葡萄膜炎及其活动相关。有必要进一步研究维生素D筛查和补充在减少葡萄膜炎复发方面的功效。
