Abstract：
OBJECTIVE: The indices to measure disease activity of chronic arthritis in adulthood and childhood are different. Therefore, assessing the status of the disease in young patients with juvenile idiopathic arthritis (JIA) can be tricky, especially when the transition to adult care is ongoing. The aim of our study was to assess the level of correlation between adult and juvenile scores in the measurement of disease activity in JIA patients during transitional care.
METHODS: We estimated the disease activity by using the Juvenile Arthritis Disease Activity Score 71 (JADAS71), clinical JADAS, adult Disease Activity Score (DAS28), Simplified Disease Activity Index (SDAI), and Clinical Disease Activity Index (CDAI) in JIA patients in transitional care. We enrolled patients older than 16 years at the time of the first transition visit, and disease activity was assessed at baseline and 12 months. Regression analyses were carried out to estimate the level of agreement among the different indices.
RESULTS: We recruited 26 patients with JIA; 11 patients were polyarticular (42.3%) and 15 patients were oligoarticular (53.1%). The mean age at diagnosis was 7.7±3.9 years and the age at the first evaluation was 20.9±3.7 years. The correlation between JADAS71 and DAS28 was r2=0.69, r2=0.86 between JADAS71 and SDAI, and r2=0.81 between JADAS71 and CDAI.
CONCLUSIONS: SDAI and JADAS71 showed the best correlation, but a few patients were not captured at the same level of disease activity. New prospective studies with a larger number of patients will be needed in this field.
METHODS: We estimated the disease activity by using the Juvenile Arthritis Disease Activity Score 71 (JADAS71), clinical JADAS, adult Disease Activity Score (DAS28), Simplified Disease Activity Index (SDAI), and Clinical Disease Activity Index (CDAI) in JIA patients in transitional care. We enrolled patients older than 16 years at the time of the first transition visit, and disease activity was assessed at baseline and 12 months. Regression analyses were carried out to estimate the level of agreement among the different indices.
RESULTS: We recruited 26 patients with JIA; 11 patients were polyarticular (42.3%) and 15 patients were oligoarticular (53.1%). The mean age at diagnosis was 7.7±3.9 years and the age at the first evaluation was 20.9±3.7 years. The correlation between JADAS71 and DAS28 was r2=0.69, r2=0.86 between JADAS71 and SDAI, and r2=0.81 between JADAS71 and CDAI.
CONCLUSIONS: SDAI and JADAS71 showed the best correlation, but a few patients were not captured at the same level of disease activity. New prospective studies with a larger number of patients will be needed in this field.
摘要：
目的：成人和儿童期慢性关节炎疾病活动度的指标不同。因此,评估青少年特发性关节炎（JIA）的年轻患者的疾病状况可能很棘手，特别是当过渡到成人护理正在进行中。我们研究的目的是评估过渡护理期间JIA患者疾病活动测量中成人和青少年得分之间的相关性水平。
方法：我们通过使用青少年关节炎疾病活动评分71（JADAS71）估计疾病活动，临床JADAS，成人疾病活动评分（DAS28），简化疾病活动指数(SDAI)JIA患者在过渡期护理中的临床疾病活动指数(CDAI)。我们在第一次过渡就诊时招募了16岁以上的患者，在基线和12个月时评估疾病活动性.进行回归分析以估计不同指标之间的一致性水平。
结果：我们招募了26例JIA患者；11例患者为多关节（42.3％），15例患者为少关节（53.1％）。诊断时的平均年龄为7.7±3.9岁，首次评估时的平均年龄为20.9±3.7岁。JADAS71与DAS28的相关性为r2=0.69,JADAS71与SDAI的r2=0.86,JADAS71和CDAI之间的r2=0.81。
结论：SDAI和JADAS71显示出最佳的相关性，但是少数患者没有在相同的疾病活动水平下被捕获。在该领域将需要具有更多患者的新的前瞻性研究。
方法：我们通过使用青少年关节炎疾病活动评分71（JADAS71）估计疾病活动，临床JADAS，成人疾病活动评分（DAS28），简化疾病活动指数(SDAI)JIA患者在过渡期护理中的临床疾病活动指数(CDAI)。我们在第一次过渡就诊时招募了16岁以上的患者，在基线和12个月时评估疾病活动性.进行回归分析以估计不同指标之间的一致性水平。
结果：我们招募了26例JIA患者；11例患者为多关节（42.3％），15例患者为少关节（53.1％）。诊断时的平均年龄为7.7±3.9岁，首次评估时的平均年龄为20.9±3.7岁。JADAS71与DAS28的相关性为r2=0.69,JADAS71与SDAI的r2=0.86,JADAS71和CDAI之间的r2=0.81。
结论：SDAI和JADAS71显示出最佳的相关性，但是少数患者没有在相同的疾病活动水平下被捕获。在该领域将需要具有更多患者的新的前瞻性研究。
