PDF(Pubmed)
Abstract：
Socially coordinated threat responses support the survival of animal groups. Given their distinct social roles, males and females must differ in such coordination. Here, we report such differences during the synchronization of auditory-conditioned freezing in mouse dyads. To study the interaction of emotional states with social cues underlying synchronization, we modulated emotional states with prior stress or modified the social cues by pairing unfamiliar or opposite-sex mice. In same-sex dyads, males exhibited more robust synchrony than females. Stress disrupted male synchrony in a prefrontal cortex-dependent manner but enhanced it in females. Unfamiliarity moderately reduced synchrony in males but not in females. In dyads with opposite-sex partners, fear synchrony was resilient to both stress and unfamiliarity. Decomposing the synchronization process in the same-sex dyads revealed sex-specific behavioral strategies correlated with synchrony magnitude: following partners\' state transitions in males and retroacting synchrony-breaking actions in females. Those were altered by stress and unfamiliarity. The opposite-sex dyads exhibited no synchrony-correlated strategy. These findings reveal sex-specific adaptations of socio-emotional integration defining coordinated behavior and suggest that sex-recognition circuits confer resilience to stress and unfamiliarity in opposite-sex dyads.
摘要：
社会协调的威胁反应支持动物群体的生存。鉴于他们独特的社会角色，男性和女性在这种协调上必须有所不同。这里,我们报告了在小鼠二元听觉条件冷冻同步过程中的这种差异。为了研究情绪状态与潜在同步的社会线索之间的相互作用，我们通过先前的压力来调节情绪状态，或者通过配对陌生或异性小鼠来改变社交线索。在同性二叉中，男性比女性表现出更强的同步性。压力以前额叶皮层依赖的方式破坏了男性的同步性，但在女性中却增强了这种同步性。不熟悉性适度降低了男性的同步性，而女性则没有。在有异性伴侣的双体中，恐惧同步对压力和陌生都有弹性。分解同性二叉中的同步过程揭示了与同步程度相关的性别特定行为策略：男性中跟随伴侣的状态转变，女性中逆转同步破坏行为。这些因压力和陌生而改变。异性二元没有表现出同步相关的策略。这些发现揭示了定义协调行为的社会情感整合的性别特异性适应，并表明性别识别回路赋予了异性双体对压力和陌生的抵抗力。
