PDF(Pubmed)
Abstract：
BACKGROUND: Late-life depression (LLD) is a prevalent neuropsychiatric disorder in the older population. While LLD exhibits high mortality rates, depressive symptoms in older adults are often masked by physical health conditions. In younger adults, depression is associated with deficits in pupil light reflex and eye blink rate, suggesting the potential use of these responses as biomarkers for LLD.
METHODS: We conducted a study using video-based eye-tracking to investigate pupil and blink responses in LLD patients (n = 25), older (OLD) healthy controls (n = 29), and younger (YOUNG) healthy controls (n = 25). The aim was to determine whether there were alterations in pupil and blink responses in LLD compared to both OLD and YOUNG groups.
RESULTS: LLD patients displayed significantly higher blink rates and dampened pupil constriction responses compared to OLD and YOUNG controls. While tonic pupil size in YOUNG differed from that of OLD, LLD patients did not exhibit a significant difference compared to OLD and YOUNG controls. GDS-15 scores in older adults correlated with light and darkness reflex response variability and blink rates. PHQ-15 scores showed a correlation with blink rates, while MoCA scores correlated with tonic pupil sizes.
CONCLUSIONS: The findings demonstrate that LLD patients display altered pupil and blink behavior compared to OLD and YOUNG controls. These altered responses correlated differently with the severity of depressive, somatic, and cognitive symptoms, indicating their potential as objective biomarkers for LLD.
METHODS: We conducted a study using video-based eye-tracking to investigate pupil and blink responses in LLD patients (n = 25), older (OLD) healthy controls (n = 29), and younger (YOUNG) healthy controls (n = 25). The aim was to determine whether there were alterations in pupil and blink responses in LLD compared to both OLD and YOUNG groups.
RESULTS: LLD patients displayed significantly higher blink rates and dampened pupil constriction responses compared to OLD and YOUNG controls. While tonic pupil size in YOUNG differed from that of OLD, LLD patients did not exhibit a significant difference compared to OLD and YOUNG controls. GDS-15 scores in older adults correlated with light and darkness reflex response variability and blink rates. PHQ-15 scores showed a correlation with blink rates, while MoCA scores correlated with tonic pupil sizes.
CONCLUSIONS: The findings demonstrate that LLD patients display altered pupil and blink behavior compared to OLD and YOUNG controls. These altered responses correlated differently with the severity of depressive, somatic, and cognitive symptoms, indicating their potential as objective biomarkers for LLD.
摘要：
背景：晚年抑郁症（LLD）是老年人群普遍存在的神经精神疾病。虽然LLD表现出很高的死亡率，老年人的抑郁症状通常被身体健康状况掩盖。在年轻人中，抑郁症与瞳孔光反射和眨眼率的缺陷有关，提示这些反应作为LLD生物标志物的潜在用途。
方法：我们进行了一项基于视频的眼动追踪研究，以调查LLD患者（n=25）的瞳孔和眨眼反应，老年（老年）健康对照（n=29），和年轻（年轻）健康对照（n=25）。目的是确定与OLD和YOUNG组相比，LLD的瞳孔和眨眼反应是否有改变。
结果：与OLD和YOUNG对照组相比，LLD患者的眨眼率和瞳孔收缩反应明显更高。虽然青少年的补品瞳孔大小与老年人不同，与OLD和YOUNG对照组相比，LLD患者没有显着差异。老年人的GDS-15得分与明暗反射反应变异性和眨眼率相关。PHQ-15得分显示与眨眼率相关，而MoCA评分与补品瞳孔大小相关。
结论：研究结果表明，与老年和青年对照组相比，LLD患者的瞳孔和眨眼行为发生了改变。这些改变的反应与抑郁的严重程度有不同的相关性，躯体,和认知症状，表明它们作为LLD客观生物标志物的潜力。
方法：我们进行了一项基于视频的眼动追踪研究，以调查LLD患者（n=25）的瞳孔和眨眼反应，老年（老年）健康对照（n=29），和年轻（年轻）健康对照（n=25）。目的是确定与OLD和YOUNG组相比，LLD的瞳孔和眨眼反应是否有改变。
结果：与OLD和YOUNG对照组相比，LLD患者的眨眼率和瞳孔收缩反应明显更高。虽然青少年的补品瞳孔大小与老年人不同，与OLD和YOUNG对照组相比，LLD患者没有显着差异。老年人的GDS-15得分与明暗反射反应变异性和眨眼率相关。PHQ-15得分显示与眨眼率相关，而MoCA评分与补品瞳孔大小相关。
结论：研究结果表明，与老年和青年对照组相比，LLD患者的瞳孔和眨眼行为发生了改变。这些改变的反应与抑郁的严重程度有不同的相关性，躯体,和认知症状，表明它们作为LLD客观生物标志物的潜力。
