PDF(Pubmed)
Abstract：
Antibiotic resistance among bacteria is recognized as the primary factor contributing to the failure of treatment. In this research, our objective was to examine the prevalence of antibiotic resistance in H. pylori bacteria in Palestine. We enlisted 91 individuals suffering from dyspepsia, comprising 49 females and 42 males. These participants underwent esophagogastroduodenoscopy procedures with gastric biopsies. These biopsies were subsequently subjected to microbiological assessments and tested for their susceptibility to various antimicrobial drugs. Among the 91 patients, 38 (41.7%) exhibited the presence of H. pylori. Notably, Ciprofloxacin displayed the highest efficacy against H. pylori, followed by Levofloxacin, Moxifloxacin, and Amoxicillin, with resistance rates of 0%, 0%, 2.6%, and 18.4%, respectively. On the contrary, Metronidazole and Clarithromycin demonstrated the lowest effectiveness, with resistance percentages of 100% and 47.4%, respectively. The outcomes of this investigation emphasize that H. pylori strains within the Palestinian patient group exhibit substantial resistance to conventional first-line antibiotics like clarithromycin and metronidazole. However, alternative agents such as fluoroquinolones and amoxicillin remain efficacious choices. Consequently, we recommend favoring quinolone-based treatment regimens for H. pylori infections and adopting a more judicious approach to antibiotic usage among the Palestinian population.
摘要：
细菌中的抗生素耐药性被认为是导致治疗失败的主要因素。在这项研究中,我们的目的是研究巴勒斯坦幽门螺杆菌对抗生素的耐药性.我们招募了91名消化不良患者，包括49名女性和42名男性。这些参与者接受了食管胃十二指肠镜检查和胃活检。随后对这些活组织检查进行微生物学评估，并测试其对各种抗微生物药物的敏感性。在91名患者中，38例(41.7%)表现出幽门螺杆菌的存在。值得注意的是,环丙沙星对幽门螺杆菌的疗效最高，其次是左氧氟沙星,莫西沙星,和阿莫西林,耐药率为0%，0%,2.6%,和18.4%，分别。相反,甲硝唑和克拉霉素的有效性最低，电阻百分比为100%和47.4%，分别。这项研究的结果强调，巴勒斯坦患者组中的幽门螺杆菌菌株对传统的一线抗生素如克拉霉素和甲硝唑表现出实质性的耐药性。然而,替代药物如氟喹诺酮和阿莫西林仍然是有效的选择.因此,我们建议支持以喹诺酮为基础的幽门螺杆菌感染治疗方案,并在巴勒斯坦人群中采用更明智的抗生素使用方法.
