Abstract：
OBJECTIVE: The incidence of pituitary neuroendocrine tumors has been reported high at autopsy. This study aimed to detect many tumors in both anterior and posterior lobes to prove tumor histogenesis.
METHODS: In total, 150 pituitary glands were studied from the University of Kansas Medical Center from 1995 to 2000. The pituitary gland was sagittally sliced from anterior to posterior into 6 to 8 sections. When H&E-stained sections revealed tumors, the tumors were immunohistochemically stained for 6 pituitary hormones.
RESULTS: Among 150 autopsy cases, 38 (25.3%) harbored microadenomas, including 4 cases with double tumors. Twenty-three (54.7%) cases were negative to all pituitary hormones. Of the remaining 19 tumors, 13 (30.9%) were lactotrophs, with 4 cases being concomitantly somatotrophs and gonadotrophs, and 2 cases were corticotropes. More than 85% of pituitary neuroendocrine tumors were adjacent to the capsule. Thirteen (8.7%) granular cell pituicytomas were found in the posterior lobe. There were pituicytes transforming into granular cell tumors.
CONCLUSIONS: The incidence was 25.3% for pituitary neuroendocrine tumors and 8.7% for granular cell pituicytomas. Since most pituitary neuroendocrine tumors were adjacent to the pituitary capsule, the capsule appeared to be the germinal center. Both pituitary tumors belonged to the 2 different transcription factor lineages.
METHODS: In total, 150 pituitary glands were studied from the University of Kansas Medical Center from 1995 to 2000. The pituitary gland was sagittally sliced from anterior to posterior into 6 to 8 sections. When H&E-stained sections revealed tumors, the tumors were immunohistochemically stained for 6 pituitary hormones.
RESULTS: Among 150 autopsy cases, 38 (25.3%) harbored microadenomas, including 4 cases with double tumors. Twenty-three (54.7%) cases were negative to all pituitary hormones. Of the remaining 19 tumors, 13 (30.9%) were lactotrophs, with 4 cases being concomitantly somatotrophs and gonadotrophs, and 2 cases were corticotropes. More than 85% of pituitary neuroendocrine tumors were adjacent to the capsule. Thirteen (8.7%) granular cell pituicytomas were found in the posterior lobe. There were pituicytes transforming into granular cell tumors.
CONCLUSIONS: The incidence was 25.3% for pituitary neuroendocrine tumors and 8.7% for granular cell pituicytomas. Since most pituitary neuroendocrine tumors were adjacent to the pituitary capsule, the capsule appeared to be the germinal center. Both pituitary tumors belonged to the 2 different transcription factor lineages.
摘要：
目的：据报道，尸检时垂体神经内分泌肿瘤的发病率很高。这项研究旨在检测前叶和后叶的许多肿瘤，以证明肿瘤的组织发生。
方法：总共，从1995年到2000年，堪萨斯大学医学中心研究了150个垂体腺。将垂体从前到后矢状切成6到8个切片。当H&E染色切片显示肿瘤时，对肿瘤进行6种垂体激素的免疫组织化学染色。
结果：在150例尸检病例中，38例（25.3%）有微腺瘤，其中双瘤4例。23例（54.7％）对所有垂体激素均呈阴性。剩下的19个肿瘤,13人(30.9%)是催乳素，4例同时患有生长激素和促性腺激素，2例为促肾上腺皮质激素。超过85％的垂体神经内分泌肿瘤与胶囊相邻。在后叶中发现了13个（8.7％）颗粒细胞垂体细胞瘤。有垂体细胞转化为颗粒细胞瘤。
结论：垂体神经内分泌肿瘤的发病率为25.3%，颗粒细胞垂体细胞瘤的发病率为8.7%。由于大多数垂体神经内分泌肿瘤与垂体囊相邻，胶囊似乎是生发中心。两种垂体瘤都属于2种不同的转录因子谱系。
方法：总共，从1995年到2000年，堪萨斯大学医学中心研究了150个垂体腺。将垂体从前到后矢状切成6到8个切片。当H&E染色切片显示肿瘤时，对肿瘤进行6种垂体激素的免疫组织化学染色。
结果：在150例尸检病例中，38例（25.3%）有微腺瘤，其中双瘤4例。23例（54.7％）对所有垂体激素均呈阴性。剩下的19个肿瘤,13人(30.9%)是催乳素，4例同时患有生长激素和促性腺激素，2例为促肾上腺皮质激素。超过85％的垂体神经内分泌肿瘤与胶囊相邻。在后叶中发现了13个（8.7％）颗粒细胞垂体细胞瘤。有垂体细胞转化为颗粒细胞瘤。
结论：垂体神经内分泌肿瘤的发病率为25.3%，颗粒细胞垂体细胞瘤的发病率为8.7%。由于大多数垂体神经内分泌肿瘤与垂体囊相邻，胶囊似乎是生发中心。两种垂体瘤都属于2种不同的转录因子谱系。
