PDF(Pubmed)
Abstract：
OBJECTIVE: Subluxation of the crystalline lens (Ectopia Lentis, EL) can lead to significant visual impairment and serves as a diagnostic criterion for genetic disorders such as the Marfan syndrome. There is no established criterion to diagnose and quantify EL. We prospectively investigated the distance between the zonular fibre insertion and the limbus (ZLD) in healthy subjects as a parameter to assess the position of the lens, quantify EL and provide normative data.
METHODS: This prospective, observational, cross-sectional study includes one-hundred-fifty eyes of 150 healthy participants (mean age 28 years, range 4-68). Pupils were dilated with tropicamide 0.5% and phenylephrine 2.5% eyedrops. ZLD was measured in mydriasis at the slit lamp as the distance between the most central visible insertions of the zonular fibres on the lens surface and the corneoscleral limbus. Vertical pupil diameter (PD) and refractive error were recorded. If zonular fibre insertions were not visible, the distance between limbus and the pupillary margin was recorded as ZLD.
RESULTS: 145 right and 5 left eyes were examined. 93% of study subjects were Caucasian, 7% were Asian. In eyes with visible zonular fibre insertions (n = 76 eyes), ZLD was 1.30 ± 0.28 mm (mean ± SD, range 0.7-2.1) and PD was 8.79 ± 0.57 mm (7.5-9.8). In the remaining 74 eyes, ZLD was 1.38 ± 0.28 mm (0.7-2.1), and PD was 8.13 ± 0.58 mm (6.7-9.4). For all eyes, ZLD was 1.34 ± 0.29 mm (0.7-2.1), and PD was 8.47 ± 0.66 mm (6.7-9.8). Refractive error and sex did not significantly affect ZLD. Smaller PD and older age were associated with larger ZLD (P < 0.001 and P = 0.036, respectively).
CONCLUSIONS: Average ZLD was 1.34 mm in eyes of healthy subjects. Older age correlated with larger ZLD. These normative data will aid in diagnosing and quantifying EL.
METHODS: This prospective, observational, cross-sectional study includes one-hundred-fifty eyes of 150 healthy participants (mean age 28 years, range 4-68). Pupils were dilated with tropicamide 0.5% and phenylephrine 2.5% eyedrops. ZLD was measured in mydriasis at the slit lamp as the distance between the most central visible insertions of the zonular fibres on the lens surface and the corneoscleral limbus. Vertical pupil diameter (PD) and refractive error were recorded. If zonular fibre insertions were not visible, the distance between limbus and the pupillary margin was recorded as ZLD.
RESULTS: 145 right and 5 left eyes were examined. 93% of study subjects were Caucasian, 7% were Asian. In eyes with visible zonular fibre insertions (n = 76 eyes), ZLD was 1.30 ± 0.28 mm (mean ± SD, range 0.7-2.1) and PD was 8.79 ± 0.57 mm (7.5-9.8). In the remaining 74 eyes, ZLD was 1.38 ± 0.28 mm (0.7-2.1), and PD was 8.13 ± 0.58 mm (6.7-9.4). For all eyes, ZLD was 1.34 ± 0.29 mm (0.7-2.1), and PD was 8.47 ± 0.66 mm (6.7-9.8). Refractive error and sex did not significantly affect ZLD. Smaller PD and older age were associated with larger ZLD (P < 0.001 and P = 0.036, respectively).
CONCLUSIONS: Average ZLD was 1.34 mm in eyes of healthy subjects. Older age correlated with larger ZLD. These normative data will aid in diagnosing and quantifying EL.
摘要：
目的：晶状体的半脱位（EctopiaLentis，EL）可导致明显的视力损害，并可作为诸如Marfan综合征之类的遗传性疾病的诊断标准。没有既定的标准来诊断和量化EL。我们前瞻性地研究了健康受试者的小带纤维插入与角膜缘（ZLD）之间的距离，作为评估晶状体位置的参数，量化EL并提供规范数据。
方法：这种前瞻性，观察,横断面研究包括150名健康参与者的150只眼睛(平均年龄28岁，范围4-68）。用0.5％的托吡卡胺和2.5％的去氧肾上腺素滴眼液对学生进行扩张。ZLD在裂隙灯处的散瞳中测量为晶状体表面上带状纤维的最中心可见插入与角膜巩膜缘之间的距离。记录垂直瞳孔直径（PD）和屈光不正。如果带状纤维插入不可见，角膜缘和瞳孔边缘之间的距离记录为ZLD。
结果：检查了145只右眼和5只左眼。93％的研究对象是白种人，7%是亚洲人。在可见小带纤维插入的眼睛中（n=76只眼睛），ZLD为1.30±0.28mm(平均值±SD,范围为0.7-2.1），PD为8.79±0.57mm（7.5-9.8）。在剩下的74只眼睛里，ZLD为1.38±0.28mm(0.7-2.1),PD为8.13±0.58mm（6.7～9.4）。对于所有的眼睛，ZLD为1.34±0.29mm(0.7-2.1),PD为8.47±0.66mm（6.7-9.8）。屈光不正和性别对ZLD无显著影响。较小的PD和年龄较大与较大的ZLD相关（分别为P<0.001和P=0.036）。
结论：健康受试者的平均ZLD为1.34mm。年龄较大与ZLD较大相关。这些规范数据将有助于诊断和量化EL。
方法：这种前瞻性，观察,横断面研究包括150名健康参与者的150只眼睛(平均年龄28岁，范围4-68）。用0.5％的托吡卡胺和2.5％的去氧肾上腺素滴眼液对学生进行扩张。ZLD在裂隙灯处的散瞳中测量为晶状体表面上带状纤维的最中心可见插入与角膜巩膜缘之间的距离。记录垂直瞳孔直径（PD）和屈光不正。如果带状纤维插入不可见，角膜缘和瞳孔边缘之间的距离记录为ZLD。
结果：检查了145只右眼和5只左眼。93％的研究对象是白种人，7%是亚洲人。在可见小带纤维插入的眼睛中（n=76只眼睛），ZLD为1.30±0.28mm(平均值±SD,范围为0.7-2.1），PD为8.79±0.57mm（7.5-9.8）。在剩下的74只眼睛里，ZLD为1.38±0.28mm(0.7-2.1),PD为8.13±0.58mm（6.7～9.4）。对于所有的眼睛，ZLD为1.34±0.29mm(0.7-2.1),PD为8.47±0.66mm（6.7-9.8）。屈光不正和性别对ZLD无显著影响。较小的PD和年龄较大与较大的ZLD相关（分别为P<0.001和P=0.036）。
结论：健康受试者的平均ZLD为1.34mm。年龄较大与ZLD较大相关。这些规范数据将有助于诊断和量化EL。
