Abstract：
Microspheres are micrometer-sized particles that can load and gradually release drugs via physical encapsulation or adsorption onto the surface and within polymers. In the field of biomedicine, hydrogel microspheres have been extensively studied for their application as drug carriers owing to their ability to reduce the frequency of drug administration, minimize side effects, and improve patient compliance. Sodium alginate (ALG) is a naturally occurring linear polysaccharide with three backbone glycosidic linkages. There are two auxiliary hydroxyl groups present in each of the moieties of the polymer, which have the characteristics of an alcohol hydroxyl moiety. The synthetic ALG units can undergo chemical cross-linking reactions with metal ions, forming a cross-linked network structure of polymer stacks, ultimately forming a hydrogel. Hydrogel microspheres can be prepared using a simple process involving the ionic cross-linking properties of ALG. In this study, we prepared ALG-based hydrogel microspheres (ALGMS) using a microfluidic electrodeposition strategy. The prepared hydrogel microspheres were uniformly sized and well-dispersed, owing to accurate control of the microfluidic electrospray flow. ALGMS cross-linked with different metal ions were prepared using a microfluidic electrospray technique combining microfluidic and high electric field, and its antimicrobial properties, slow drug release ability, and biocompatibility were investigated. This technology holds promise for application in advanced drug development and production.
摘要：
微球是微米级的颗粒，可以通过物理封装或吸附到聚合物表面和内部来加载和逐渐释放药物。在生物医学领域,由于水凝胶微球能够降低给药频率，因此其作为药物载体的应用已被广泛研究。尽量减少副作用，提高患者的依从性。藻酸钠(ALG)是具有三个主链糖苷键的天然存在的线性多糖。在聚合物的每个部分中存在两个辅助羟基，具有醇羟基部分的特征。合成的ALG单元可以与金属离子进行化学交联反应，形成聚合物叠层的交联网络结构，最终形成水凝胶。水凝胶微球可以使用涉及ALG的离子交联性质的简单方法制备。在这项研究中,我们使用微流体电沉积策略制备了基于ALG的水凝胶微球（ALGMS）。制备的水凝胶微球大小均匀、分散良好,由于微流体电喷雾流的精确控制。使用微流体和高电场相结合的微流体电喷雾技术制备了与不同金属离子交联的ALGMS，和它的抗菌特性，缓慢的药物释放能力，和生物相容性进行了研究。该技术有望应用于先进的药物开发和生产。
