PDF(Pubmed)
Abstract：
Helicobacter pylori (H. pylori) is a strict microaerophilic bacterial species that exists in the stomach, and H. pylori infection is one of the most common chronic bacterial infections affecting humans. Eradicating H. pylori is the preferred method for the long-term prevention of complications such as chronic gastritis, peptic ulcers, gastric mucosa-associated lymphoid tissue lymphoma, and gastric cancer. However, first-line treatment with triple therapy and quadruple therapy has been unable to cope with increasing antibacterial resistance. To provide an updated review of H. pylori infections and antibacterial resistance, as well as related treatment options, we searched PubMed for articles published until March 2024. The key search terms were \"H. pylori\", \"H. pylori infection\", \"H. pylori diseases\", \"H. pylori eradication\", and \"H. pylori antibacterial resistance.\" Despite the use of antimicrobial agents, the annual decline in the eradication rate of H. pylori continues. Emerging eradication therapies, such as the development of the new strong acid blocker vonoprazan, probiotic adjuvant therapy, and H. pylori vaccine therapy, are exciting. However, the effectiveness of these treatments needs to be further evaluated. It is worth mentioning that the idea of altering the oxygen environment in gastric juice for H. pylori to not be able to survive is a hot topic that should be considered in new eradication plans. Various strategies for eradicating H. pylori, including antibacterials, vaccines, probiotics, and biomaterials, are continuously evolving. A novel approach involving the alteration of the oxygen concentration within the growth environment of H. pylori has emerged as a promising eradication strategy.
摘要：
幽门螺杆菌(H.幽门螺杆菌）是存在于胃中的严格的微需氧细菌物种，幽门螺杆菌感染是影响人类的最常见的慢性细菌感染之一。根除幽门螺杆菌是长期预防慢性胃炎等并发症的首选方法,消化性溃疡,胃粘膜相关淋巴组织淋巴瘤，还有胃癌.然而,三联疗法和四联疗法的一线治疗无法应对不断增加的抗菌药物耐药性。提供幽门螺杆菌感染和抗菌药物耐药性的最新综述，以及相关的治疗方案，我们搜索了PubMed直到2024年3月发表的文章。关键搜索词是\"H.幽门螺杆菌“，\"H.幽门螺杆菌感染“，\"H.幽门螺杆菌疾病“，\"H.根除幽门螺杆菌“，和“H”。幽门螺杆菌抗菌抗性。“尽管使用了抗菌剂，幽门螺杆菌根除率的逐年下降.新兴的根除疗法，如开发新的强酸阻滞剂沃诺拉赞，益生菌辅助治疗,和幽门螺杆菌疫苗治疗，令人兴奋。然而,这些治疗的有效性需要进一步评估.值得一提的是，改变胃液中的氧气环境使幽门螺杆菌无法生存的想法是新的根除计划中应考虑的热门话题。根除幽门螺杆菌的各种策略，包括抗菌药物,疫苗,益生菌，和生物材料，不断发展。一种涉及改变幽门螺杆菌生长环境中氧浓度的新方法已成为有希望的根除策略。
