PDF(Pubmed)
Abstract：
BACKGROUND: Recent work suggests that amyloid beta (Aβ) positron emission tomography (PET) tracer uptake shortly after injection (\"early phase\") reflects brain metabolism and perfusion. We assessed this modality in a predominantly amyloid-negative neurodegenerative condition, Parkinson\'s disease (PD), and hypothesized that early-phase 18F-florbetaben (eFBB) uptake would reproduce characteristic hypometabolism and hypoperfusion patterns associated with cognitive decline in PD.
METHODS: One hundred fifteen PD patients across the spectrum of cognitive impairment underwent dual-phase Aβ PET, structural and arterial spin labeling (ASL) magnetic resonance imaging (MRI), and neuropsychological assessments. Multiple linear regression models compared eFBB uptake to cognitive performance and ASL MRI perfusion.
RESULTS: Reduced eFBB uptake was associated with cognitive performance in brain regions previously linked to hypometabolism-associated cognitive decline in PD, independent of amyloid status. Furthermore, eFBB uptake correlated with cerebral perfusion across widespread regions.
CONCLUSIONS: EFBB uptake is a potential surrogate measure for cerebral perfusion/metabolism. A dual-phase PET imaging approach may serve as a clinical tool for assessing cognitive impairment.
UNASSIGNED: Images taken at amyloid beta (Aβ) positron emission tomography tracer injection may reflect brain perfusion and metabolism.Parkinson\'s disease (PD) is a predominantly amyloid-negative condition.Early-phase florbetaben (eFBB) in PD was associated with cognitive performance.eFBB uptake reflects hypometabolism-related cognitive decline in PD.eFBB correlated with arterial spin labeling magnetic resonance imaging measured cerebral perfusion.eFBB distinguished dementia from normal cognition and mild cognitive impairment.Findings were independent of late-phase Aβ burden.Thus, eFBB may serve as a surrogate measure for brain metabolism/perfusion.
METHODS: One hundred fifteen PD patients across the spectrum of cognitive impairment underwent dual-phase Aβ PET, structural and arterial spin labeling (ASL) magnetic resonance imaging (MRI), and neuropsychological assessments. Multiple linear regression models compared eFBB uptake to cognitive performance and ASL MRI perfusion.
RESULTS: Reduced eFBB uptake was associated with cognitive performance in brain regions previously linked to hypometabolism-associated cognitive decline in PD, independent of amyloid status. Furthermore, eFBB uptake correlated with cerebral perfusion across widespread regions.
CONCLUSIONS: EFBB uptake is a potential surrogate measure for cerebral perfusion/metabolism. A dual-phase PET imaging approach may serve as a clinical tool for assessing cognitive impairment.
UNASSIGNED: Images taken at amyloid beta (Aβ) positron emission tomography tracer injection may reflect brain perfusion and metabolism.Parkinson\'s disease (PD) is a predominantly amyloid-negative condition.Early-phase florbetaben (eFBB) in PD was associated with cognitive performance.eFBB uptake reflects hypometabolism-related cognitive decline in PD.eFBB correlated with arterial spin labeling magnetic resonance imaging measured cerebral perfusion.eFBB distinguished dementia from normal cognition and mild cognitive impairment.Findings were independent of late-phase Aβ burden.Thus, eFBB may serve as a surrogate measure for brain metabolism/perfusion.
摘要：
背景：最近的研究表明，β淀粉样蛋白（Aβ）正电子发射断层扫描（PET）示踪剂在注射后不久（“早期阶段”）摄取反映了脑代谢和灌注。我们在主要为淀粉样蛋白阴性的神经退行性疾病中评估了这种模式，帕金森病（PD），并假设早期阶段的18F-氟贝他班（eFBB）摄取会重现与PD认知下降相关的特征性低代谢和低灌注模式。
方法：150名认知功能障碍的PD患者接受了双相AβPET，结构和动脉自旋标记（ASL）磁共振成像（MRI），和神经心理学评估。多元线性回归模型将eFBB摄取与认知表现和ASLMRI灌注进行了比较。
结果：降低的eFBB摄取与先前与PD的低代谢相关的认知下降有关的大脑区域的认知表现有关，独立于淀粉样蛋白状态。此外，eFBB摄取与广泛区域的脑灌注相关。
结论：EFBB摄取是脑灌注/代谢的潜在替代指标。双相PET成像方法可以作为评估认知障碍的临床工具。
■在淀粉样蛋白β（Aβ）正电子发射断层扫描示踪剂注射时拍摄的图像可能反映了脑灌注和代谢。帕金森病(PD)是一种主要为淀粉样蛋白阴性的疾病。PD早期阶段氟倍他班(eFBB)与认知能力相关。eFBB摄取反映了PD中与代谢低相关的认知下降。eFBB与动脉自旋标记磁共振成像测量的脑灌注相关。eFBB将痴呆与正常认知和轻度认知损害区分开来。研究结果与后期Aβ负荷无关。因此，eFBB可以作为脑代谢/灌注的替代测量。
方法：150名认知功能障碍的PD患者接受了双相AβPET，结构和动脉自旋标记（ASL）磁共振成像（MRI），和神经心理学评估。多元线性回归模型将eFBB摄取与认知表现和ASLMRI灌注进行了比较。
结果：降低的eFBB摄取与先前与PD的低代谢相关的认知下降有关的大脑区域的认知表现有关，独立于淀粉样蛋白状态。此外，eFBB摄取与广泛区域的脑灌注相关。
结论：EFBB摄取是脑灌注/代谢的潜在替代指标。双相PET成像方法可以作为评估认知障碍的临床工具。
■在淀粉样蛋白β（Aβ）正电子发射断层扫描示踪剂注射时拍摄的图像可能反映了脑灌注和代谢。帕金森病(PD)是一种主要为淀粉样蛋白阴性的疾病。PD早期阶段氟倍他班(eFBB)与认知能力相关。eFBB摄取反映了PD中与代谢低相关的认知下降。eFBB与动脉自旋标记磁共振成像测量的脑灌注相关。eFBB将痴呆与正常认知和轻度认知损害区分开来。研究结果与后期Aβ负荷无关。因此，eFBB可以作为脑代谢/灌注的替代测量。
