{Reference Type}: Journal Article
{Title}: Early-phase amyloid PET reproduces metabolic signatures of cognitive decline in Parkinson's disease.
{Author}: Aye WWT;Stark MR;Horne KL;Livingston L;Grenfell S;Myall DJ;Pitcher TL;Almuqbel MM;Keenan RJ;Meissner WG;Dalrymple-Alford JC;Anderson TJ;Heron CL;Melzer TR;
{Journal}: Alzheimers Dement (Amst)
{Volume}: 16
{Issue}: 2
{Year}: 2024 Apr-Jun
暂无{DOI}: 10.1002/dad2.12601
{Abstract}: <B>BACKGROUND: </B>Recent work suggests that amyloid beta (Aβ) positron emission tomography (PET) tracer uptake shortly after injection ("early phase") reflects brain metabolism and perfusion. We assessed this modality in a predominantly amyloid-negative neurodegenerative condition, Parkinson's disease (PD), and hypothesized that early-phase 18F-florbetaben (eFBB) uptake would reproduce characteristic hypometabolism and hypoperfusion patterns associated with cognitive decline in PD.<BR><B>METHODS: </B>One hundred fifteen PD patients across the spectrum of cognitive impairment underwent dual-phase Aβ PET, structural and arterial spin labeling (ASL) magnetic resonance imaging (MRI), and neuropsychological assessments. Multiple linear regression models compared eFBB uptake to cognitive performance and ASL MRI perfusion.<BR><B>RESULTS: </B>Reduced eFBB uptake was associated with cognitive performance in brain regions previously linked to hypometabolism-associated cognitive decline in PD, independent of amyloid status. Furthermore, eFBB uptake correlated with cerebral perfusion across widespread regions.<BR><B>CONCLUSIONS: </B>EFBB uptake is a potential surrogate measure for cerebral perfusion/metabolism. A dual-phase PET imaging approach may serve as a clinical tool for assessing cognitive impairment.<BR><B>UNASSIGNED: </B>Images taken at amyloid beta (Aβ) positron emission tomography tracer injection may reflect brain perfusion and metabolism.Parkinson's disease (PD) is a predominantly amyloid-negative condition.Early-phase florbetaben (eFBB) in PD was associated with cognitive performance.eFBB uptake reflects hypometabolism-related cognitive decline in PD.eFBB correlated with arterial spin labeling magnetic resonance imaging measured cerebral perfusion.eFBB distinguished dementia from normal cognition and mild cognitive impairment.Findings were independent of late-phase Aβ burden.Thus, eFBB may serve as a surrogate measure for brain metabolism/perfusion.