PDF(Pubmed)
Abstract：
UNASSIGNED: This meta-analysis aimed to investigate the association between mean platelet volume (MPV) and systemic lupus erythematosus (SLE) disease activity, and laboratory parameters including the SLE Disease Activity Index (SLEDAI), C3 levels, anti-double-stranded DNA (anti-dsDNA) antibodies, and erythrocyte sedimentation rate (ESR).
UNASSIGNED: The Medline, Embase, and Cochrane databases were searched comprehensively to identify relevant articles. Meta-Analyses were performed to assess differences in MPV between patients with SLE and control groups and between active and inactive SLE. A separate meta-analysis explored correlation coefficients between MPV and SLEDAI, C3, anti-dsDNA, and ESR.
UNASSIGNED: Fourteen studies comprising 659 patients with SLE and 682 controls were included. No significant difference in MPV was found between patients with SLE and control groups (standardized mean difference [SMD]: 0.406; 95% confidence interval [CI]: -0.087 to 0.899; P = 0.107). When stratified by ethnicity, the Arab population displayed markedly elevated MPV levels within the SLE group (SMD: 1.032; 95% CI: 0.475-1.588; P <0.001), unlike their European and Asian counterparts. MPV levels were higher in the active disease group than in the inactive group, particularly among the Arab population (SMD: 2.100; 95% CI: 0.406-3.794; P = 0.015), while no significant difference was observed within the Asian population (SMD: -1.493; 95% CI = -4.465 to 1.479; P = 0.325). MPV did not correlate with SLEDAI (correlation coefficient: 0.252; 95% CI: -0.016 to 0.486; P = 0.065), ESR, C3, or anti-dsDNA.
UNASSIGNED: MPV levels were generally higher in patients with SLE among the Arab population. Moreover, MPV and disease activity were positively correlated within the Arab population, underscoring the potential of MPV as a disease activity indicator in specific ethnic groups.
UNASSIGNED: The Medline, Embase, and Cochrane databases were searched comprehensively to identify relevant articles. Meta-Analyses were performed to assess differences in MPV between patients with SLE and control groups and between active and inactive SLE. A separate meta-analysis explored correlation coefficients between MPV and SLEDAI, C3, anti-dsDNA, and ESR.
UNASSIGNED: Fourteen studies comprising 659 patients with SLE and 682 controls were included. No significant difference in MPV was found between patients with SLE and control groups (standardized mean difference [SMD]: 0.406; 95% confidence interval [CI]: -0.087 to 0.899; P = 0.107). When stratified by ethnicity, the Arab population displayed markedly elevated MPV levels within the SLE group (SMD: 1.032; 95% CI: 0.475-1.588; P <0.001), unlike their European and Asian counterparts. MPV levels were higher in the active disease group than in the inactive group, particularly among the Arab population (SMD: 2.100; 95% CI: 0.406-3.794; P = 0.015), while no significant difference was observed within the Asian population (SMD: -1.493; 95% CI = -4.465 to 1.479; P = 0.325). MPV did not correlate with SLEDAI (correlation coefficient: 0.252; 95% CI: -0.016 to 0.486; P = 0.065), ESR, C3, or anti-dsDNA.
UNASSIGNED: MPV levels were generally higher in patients with SLE among the Arab population. Moreover, MPV and disease activity were positively correlated within the Arab population, underscoring the potential of MPV as a disease activity indicator in specific ethnic groups.
摘要：
■这项荟萃分析旨在研究平均血小板体积（MPV）与系统性红斑狼疮（SLE）疾病活动之间的关系，和实验室参数，包括SLE疾病活动指数（SLEDAI），C3级,抗双链DNA（抗dsDNA）抗体，和红细胞沉降率（ESR）。
■Medline，Embase,和Cochrane数据库进行了全面搜索，以识别相关文章。进行荟萃分析以评估SLE患者与对照组之间以及活动性和非活动性SLE之间的MPV差异。单独的荟萃分析探讨了MPV和SLEDAI之间的相关系数，C3，抗dsDNA，和ESR。
■纳入了14项研究，包括659名SLE患者和682名对照。SLE患者与对照组之间的MPV没有显着差异（标准化平均差[SMD]：0.406；95％置信区间[CI]：-0.087至0.899；P=0.107）。当按种族分层时，阿拉伯人群在SLE组中表现出明显升高的MPV水平(SMD:1.032;95%CI:0.475-1.588;P<0.001),不像他们的欧洲和亚洲同行。疾病活动期组的MPV水平高于非活动期组,特别是在阿拉伯人口中(SMD：2.100；95%CI：0.406-3.794；P=0.015)，而在亚洲人群中没有观察到显着差异（SMD：-1.493;95％CI=-4.465至1.479;P=0.325）。MPV与SLEDAI不相关(相关系数:0.252;95%CI:-0.016~0.486;P=0.065),ESR,C3或抗dsDNA。
■阿拉伯人群中SLE患者的MPV水平普遍较高。此外，在阿拉伯人口中，MPV和疾病活动呈正相关，强调MPV作为特定种族的疾病活动指标的潜力。
■Medline，Embase,和Cochrane数据库进行了全面搜索，以识别相关文章。进行荟萃分析以评估SLE患者与对照组之间以及活动性和非活动性SLE之间的MPV差异。单独的荟萃分析探讨了MPV和SLEDAI之间的相关系数，C3，抗dsDNA，和ESR。
■纳入了14项研究，包括659名SLE患者和682名对照。SLE患者与对照组之间的MPV没有显着差异（标准化平均差[SMD]：0.406；95％置信区间[CI]：-0.087至0.899；P=0.107）。当按种族分层时，阿拉伯人群在SLE组中表现出明显升高的MPV水平(SMD:1.032;95%CI:0.475-1.588;P<0.001),不像他们的欧洲和亚洲同行。疾病活动期组的MPV水平高于非活动期组,特别是在阿拉伯人口中(SMD：2.100；95%CI：0.406-3.794；P=0.015)，而在亚洲人群中没有观察到显着差异（SMD：-1.493;95％CI=-4.465至1.479;P=0.325）。MPV与SLEDAI不相关(相关系数:0.252;95%CI:-0.016~0.486;P=0.065),ESR,C3或抗dsDNA。
■阿拉伯人群中SLE患者的MPV水平普遍较高。此外，在阿拉伯人口中，MPV和疾病活动呈正相关，强调MPV作为特定种族的疾病活动指标的潜力。
