UNASSIGNED: We retrospectively included consecutive patients admitted to the ICU for a severe acute exacerbation of COPD between May 2015 and December 2018. Logistic multivariate regression analysis was performed to identify association between T0-Ph and the need for invasive MV during the ICU stay.
UNASSIGNED: We included 198 patients of whom 132 (67%) were male. The median age was 70 [interquartile range (IQR), 61-77] years. Nine (4.5%) patients died in the ICU. Median T0-Ph was significantly higher among patients requiring invasive MV as compared to non-intubated patients [1.23 (IQR, 1.07-1.41) and 1.09 (IQR, 0.91-1.27) mmol/L; P=0.005]. By multivariate analysis, pneumonia [odds ratio (OR) =6.42; 95% confidence interval (CI): 2.78-15.96; P<0.0001) and a history of intubation (OR =3.33; 95% CI: 0.97-11.19; P=0.05) were independently associated with the need for invasive MV, whereas T0-Ph was not (OR =1.75; 95% CI: 0.72-4.44; P=0.22).
UNASSIGNED: T0-Ph was significantly higher in patients requiring invasive MV. However, T0-Ph was not associated with the need for invasive MV in multivariate analysis.
我们回顾性纳入了2015年5月至2018年12月因COPD严重急性加重而入院ICU的连续患者。进行Logistic多元回归分析以确定T0-Ph与ICU住院期间侵入性MV需求之间的关联。
■我们纳入了198例患者,其中132例(67%)为男性。中位年龄为70[四分位距(IQR),61-77]年。9名(4.5%)患者在ICU死亡。与未插管的患者相比,需要侵入性MV的患者的T0-Ph中位数明显更高[1.23(IQR,1.07-1.41)和1.09(IQR,0.91-1.27)mmol/L;P=0.005]。通过多变量分析,肺炎[比值比(OR)=6.42;95%置信区间(CI):2.78-15.96;P<0.0001)和插管史(OR=3.33;95%CI:0.97-11.19;P=0.05)与侵入性MV的需要独立相关,而T0-Ph无差异(OR=1.75;95%CI:0.72-4.44;P=0.22)。
■T0-Ph在需要侵入性MV的患者中明显更高。然而,在多变量分析中,T0-Ph与侵入性MV的需要无关。