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Abstract：
Head and neck squamous cell carcinoma (HNSCC) represents the predominant malignancies in the head and neck region, and has limited therapeutic alternatives. Circular RNAs (circRNAs), a substantial category of non-coding RNA molecules, exert influential roles in human disease development and progression, employing various mechanisms such as microRNA sponging, interaction with RNA-binding proteins, and translational capabilities. Accumulating evidence highlights the differential expression of numerous circRNAs in HNSCC, and numerous dysregulated circRNAs underscore their crucial involvement in malignant advancement and resistance to treatment. This review aims to comprehensively outline the characteristics, biogenesis, and mechanisms of circRNAs, elucidating their functional significance in HNSCC. In addition, we delve into the clinical implications of circRNAs, considering their potential as biomarkers or targets for diagnosis, prognosis, and therapeutic applications in HNSCC. The discussion extends to exploring future challenges in the clinical translation of circRNAs, emphasizing the need for further research.
摘要：
头颈部鳞状细胞癌（HNSCC）是头颈部区域的主要恶性肿瘤，并且有有限的治疗选择。环状RNA（circularRNAs），一类相当大的非编码RNA分子，在人类疾病的发展和进展中发挥重要作用，采用各种机制，如microRNA海绵，与RNA结合蛋白相互作用，和翻译能力。越来越多的证据强调了HNSCC中许多circRNAs的差异表达，和许多失调的circRNAs强调了它们在恶性进展和治疗抗性中的关键参与。这篇综述旨在全面概述这些特点，生物发生，和circRNAs的机制，阐明它们在HNSCC中的功能意义。此外,我们深入研究了circRNAs的临床意义，考虑到它们作为生物标志物或诊断目标的潜力，预后,以及HNSCC中的治疗应用。讨论扩展到探索circRNAs临床翻译的未来挑战，强调需要进一步研究。
