PDF(Pubmed)
Abstract：
UNASSIGNED: Recent evidence reveals that type 1 diabetes mellitus (T1DM) impairs muscle function (MF) in adolescents. However, despite its importance in physical well-being, data on dynamic MF in Indian children and adolescents (C and Y) with T1DM are scarce. We assessed MF using Jumping Mechanography (JM, a measurement method for motion analysis and assessment of muscle power and force). (1) To assess dynamic MF by JM in C and Y with T1DM as compared to healthy controls (2) To determine predictors of MF in children with T1DM.
UNASSIGNED: A cross-sectional observational study on 266 children (133 - T1DM duration >1 year with no known comorbidities + 133 age and gender-matched healthy controls) aged 6-19 years. Anthropometry, body composition, and MF (maximum relative power Pmax/mass, maximum relative force Fmax/BW by JM) were recorded. The lean mass index (LMI) was calculated as lean mass (kg)/height (m2). HbA1c was assessed in T1DM. Independent sample t-test and linear regression were performed.
UNASSIGNED: MF parameters (Pmax/mass 33.5 ± 7.2 vs 38.0 ± 8.6 W/kg and Fmax/BW 10.5 ± 2.9 vs 11.4 ± 4.1 N/kg, P < 0.05) were significantly lower in T1DM group vs controls. Positive association of body mass index and LMI with both MF parameters and negative association of insulin requirement and HbA1c with Fmax was observed in T1DM. Predictors of MF identified were MMI (Pmax/mass:b = 1.6,95%CI = 0.6-2.6; Fmax/BW:b =2.0,95%CI = 1.6-2.4) and HbA1c (Pmax/mass:b = -2.1,95%CI = -4.5--0.5; Fmax/BW:b = -1.1,95%CI = -2.0--0.2) (P < 0.05).
UNASSIGNED: C and Y with T1DM exhibits compromised muscle function. Poor glycaemic control increases the risk of having decreased MF, irrespective of diabetes duration and may contribute to sarcopenia in adulthood.
UNASSIGNED: A cross-sectional observational study on 266 children (133 - T1DM duration >1 year with no known comorbidities + 133 age and gender-matched healthy controls) aged 6-19 years. Anthropometry, body composition, and MF (maximum relative power Pmax/mass, maximum relative force Fmax/BW by JM) were recorded. The lean mass index (LMI) was calculated as lean mass (kg)/height (m2). HbA1c was assessed in T1DM. Independent sample t-test and linear regression were performed.
UNASSIGNED: MF parameters (Pmax/mass 33.5 ± 7.2 vs 38.0 ± 8.6 W/kg and Fmax/BW 10.5 ± 2.9 vs 11.4 ± 4.1 N/kg, P < 0.05) were significantly lower in T1DM group vs controls. Positive association of body mass index and LMI with both MF parameters and negative association of insulin requirement and HbA1c with Fmax was observed in T1DM. Predictors of MF identified were MMI (Pmax/mass:b = 1.6,95%CI = 0.6-2.6; Fmax/BW:b =2.0,95%CI = 1.6-2.4) and HbA1c (Pmax/mass:b = -2.1,95%CI = -4.5--0.5; Fmax/BW:b = -1.1,95%CI = -2.0--0.2) (P < 0.05).
UNASSIGNED: C and Y with T1DM exhibits compromised muscle function. Poor glycaemic control increases the risk of having decreased MF, irrespective of diabetes duration and may contribute to sarcopenia in adulthood.
摘要：
■最近的证据表明，1型糖尿病（T1DM）会损害青少年的肌肉功能（MF）。然而,尽管它对身体健康很重要，印度儿童和青少年(C和Y)患有T1DM的动态MF数据很少。我们使用跳跃力学(JM，一种用于运动分析和评估肌肉力量和力量的测量方法)。（1）与健康对照相比，通过JM评估T1DM患者C和Y的动态MF（2）确定T1DM儿童MF的预测因子。
■一项针对266名6-19岁儿童（133-T1DM病程>1年，无已知合并症+133名年龄和性别匹配的健康对照）的横断面观察性研究。人体测量学,身体成分,和MF(最大相对功率Pmax/mass，记录JM的最大相对力Fmax/BW)。瘦质量指数(LMI)计算为瘦质量(kg)/身高(m2)。在T1DM中评估HbA1c。进行独立样本t检验和线性回归。
■MF参数（Pmax/质量33.5±7.2vs38.0±8.6W/kg，Fmax/BW10.5±2.9vs11.4±4.1N/kg，与对照组相比，T1DM组P<0.05）明显降低。在T1DM中观察到体重指数和LMI与MF参数呈正相关，胰岛素需求和HbA1c与Fmax呈负相关。确定的MF预测因子为MMI（Pmax/mass：b=1.6,95CI=0.6-2.6；Fmax/BW：b=2.0,95CI=1.6-2.4）和HbA1c（Pmax/mass：b=-2.1,95CI=-4.5--0.5；Fmax/BW：b=-1.1,95CI=-2.0--0.2）（P<0.05）。
■患有T1DM的C和Y表现出受损的肌肉功能。血糖控制不良会增加MF降低的风险，无论糖尿病持续时间如何，都可能导致成年期的肌肉减少症。
■一项针对266名6-19岁儿童（133-T1DM病程>1年，无已知合并症+133名年龄和性别匹配的健康对照）的横断面观察性研究。人体测量学,身体成分,和MF(最大相对功率Pmax/mass，记录JM的最大相对力Fmax/BW)。瘦质量指数(LMI)计算为瘦质量(kg)/身高(m2)。在T1DM中评估HbA1c。进行独立样本t检验和线性回归。
■MF参数（Pmax/质量33.5±7.2vs38.0±8.6W/kg，Fmax/BW10.5±2.9vs11.4±4.1N/kg，与对照组相比，T1DM组P<0.05）明显降低。在T1DM中观察到体重指数和LMI与MF参数呈正相关，胰岛素需求和HbA1c与Fmax呈负相关。确定的MF预测因子为MMI（Pmax/mass：b=1.6,95CI=0.6-2.6；Fmax/BW：b=2.0,95CI=1.6-2.4）和HbA1c（Pmax/mass：b=-2.1,95CI=-4.5--0.5；Fmax/BW：b=-1.1,95CI=-2.0--0.2）（P<0.05）。
■患有T1DM的C和Y表现出受损的肌肉功能。血糖控制不良会增加MF降低的风险，无论糖尿病持续时间如何，都可能导致成年期的肌肉减少症。
