PDF(Pubmed)
Abstract：
UNASSIGNED: Schizophrenia is most times a chronic and often debilitating illness associated with poor mental health outcomes. Early and effective treatment of schizophrenia in the most appropriate setting can make a significant difference in the long-term recovery. The aim of this narrative review was to provide suggestions and recommendations for effectively managing patients with schizophrenia during acute exacerbations and to enhance awareness and skills related to personalized medicine.
UNASSIGNED: A panel of academics and clinicians with experience in the field of psychosis met virtually on July 13th 2023 to narratively review and discuss the research evidence and their clinical experience about the most appropriate acute treatments for patients with schizophrenia. This manuscript represents a synthesis of the panel analysis and discussion.
UNASSIGNED: First contact is very important for service users, as is finding the most adequate treatment setting. If patients present to the emergency department, which may be a traumatic setting for service users, a dedicated environment with adequate space and specialized mental health support, including personnel trained in de-escalation techniques, is recommended. A well-connected continuum of care is strongly recommended, possibly with seamless links between inpatient units, day hospital services, outpatient facilities and rehabilitation services. Ideally, this should be structured as part of a coordinated step-down service line. Treatment challenges include suboptimal response, side effects, and nonadherence, which is reduced by the use of long-acting injectable antipsychotics.
UNASSIGNED: Individual circumstances, including age, gender, and presence of hostility/aggression or self-harm, cognitive impairment and negative symptoms, comorbidities (depression, substance use disorders) or associated symptoms (anxiety, insomnia), should be considered when selecting the most appropriate treatment for the acute phase of schizophrenia. Efficacy and feasibility, as well as acceptability and tolerability of treatments, require joint consideration from the early stages of schizophrenia, thereby enhancing the possibility of improved short- and long-term outcomes.
UNASSIGNED: A panel of academics and clinicians with experience in the field of psychosis met virtually on July 13th 2023 to narratively review and discuss the research evidence and their clinical experience about the most appropriate acute treatments for patients with schizophrenia. This manuscript represents a synthesis of the panel analysis and discussion.
UNASSIGNED: First contact is very important for service users, as is finding the most adequate treatment setting. If patients present to the emergency department, which may be a traumatic setting for service users, a dedicated environment with adequate space and specialized mental health support, including personnel trained in de-escalation techniques, is recommended. A well-connected continuum of care is strongly recommended, possibly with seamless links between inpatient units, day hospital services, outpatient facilities and rehabilitation services. Ideally, this should be structured as part of a coordinated step-down service line. Treatment challenges include suboptimal response, side effects, and nonadherence, which is reduced by the use of long-acting injectable antipsychotics.
UNASSIGNED: Individual circumstances, including age, gender, and presence of hostility/aggression or self-harm, cognitive impairment and negative symptoms, comorbidities (depression, substance use disorders) or associated symptoms (anxiety, insomnia), should be considered when selecting the most appropriate treatment for the acute phase of schizophrenia. Efficacy and feasibility, as well as acceptability and tolerability of treatments, require joint consideration from the early stages of schizophrenia, thereby enhancing the possibility of improved short- and long-term outcomes.
摘要：
精神分裂症通常是一种慢性且经常使人衰弱的疾病，与不良的心理健康结果有关。在最合适的环境中早期有效治疗精神分裂症可以对长期康复产生显着影响。这篇叙述性综述的目的是为有效管理急性加重期精神分裂症患者提供建议和建议，并提高与个性化医疗相关的意识和技能。
■一个由在精神病领域有经验的学者和临床医生组成的小组于2023年7月13日几乎开会，以叙述性的方式回顾和讨论关于精神分裂症患者最适当的急性治疗的研究证据和他们的临床经验。这份手稿代表了小组分析和讨论的综合。
■第一次接触对于服务用户非常重要，找到最适当的治疗设置。如果患者出现在急诊科，这对服务用户来说可能是一个痛苦的环境，一个有足够空间和专门心理健康支持的专用环境，包括接受过降级技术培训的人员，是推荐的。强烈建议一个连接良好的连续护理，住院单位之间可能有无缝联系，日间医院服务,门诊设施和康复服务。理想情况下,这应该作为协调降压服务线的一部分。治疗挑战包括反应欠佳，副作用,和不坚持，通过使用长效可注射抗精神病药减少。
■个人情况，包括年龄,性别,以及存在敌意/侵略或自我伤害，认知障碍和阴性症状，合并症(抑郁症，物质使用障碍)或相关症状(焦虑，失眠)，在选择最适合精神分裂症急性期的治疗方法时，应考虑。疗效和可行性，以及治疗的可接受性和耐受性，需要从精神分裂症的早期阶段共同考虑，从而提高改善短期和长期结果的可能性。
■一个由在精神病领域有经验的学者和临床医生组成的小组于2023年7月13日几乎开会，以叙述性的方式回顾和讨论关于精神分裂症患者最适当的急性治疗的研究证据和他们的临床经验。这份手稿代表了小组分析和讨论的综合。
■第一次接触对于服务用户非常重要，找到最适当的治疗设置。如果患者出现在急诊科，这对服务用户来说可能是一个痛苦的环境，一个有足够空间和专门心理健康支持的专用环境，包括接受过降级技术培训的人员，是推荐的。强烈建议一个连接良好的连续护理，住院单位之间可能有无缝联系，日间医院服务,门诊设施和康复服务。理想情况下,这应该作为协调降压服务线的一部分。治疗挑战包括反应欠佳，副作用,和不坚持，通过使用长效可注射抗精神病药减少。
■个人情况，包括年龄,性别,以及存在敌意/侵略或自我伤害，认知障碍和阴性症状，合并症(抑郁症，物质使用障碍)或相关症状(焦虑，失眠)，在选择最适合精神分裂症急性期的治疗方法时，应考虑。疗效和可行性，以及治疗的可接受性和耐受性，需要从精神分裂症的早期阶段共同考虑，从而提高改善短期和长期结果的可能性。
