关键词: Campylobacter fetus meningitis bacterial meningitis relapse

Mesh : Humans Male Adult Campylobacter fetus / isolation & purification Campylobacter Infections / drug therapy complications diagnosis microbiology Recurrence Meropenem / administration & dosage Meningitis, Bacterial / drug therapy microbiology diagnosis Anti-Bacterial Agents / administration & dosage Time Factors Minocycline / administration & dosage Treatment Outcome Thienamycins / administration & dosage Drug Therapy, Combination

来  源:   DOI:10.5692/clinicalneurol.cn-001978

Abstract:
A 43-year-old man was admitted to our department due to fever and headache. The cerebrospinal fluid analysis confirmed bacterial meningitis. Campylobacter species were isolated from blood cultures on the third day of admission. The patient was treated with meropenem (MEPM) and discharged on the 17th day. However, he experienced a recurrence of meningitis and was readmitted on the 68th day, initiating MEPM therapy. Campylobacter fetus was isolated from cerebrospinal fluid cultures on the 74th day. MEPM was continued until the 81st day, followed by one month of minocycline (MINO) therapy. The patient had an uneventful recovery without further recurrence. This case highlights the potential for recurrence of Campylobacter fetus meningitis approximately two months after the resolution of the initial infection. In addition to carbapenem therapy for at least two weeks, the adjunctive administration of MINO may be beneficial.
摘要:
一名43岁的男子因发烧和头痛入院。脑脊液分析证实细菌性脑膜炎。在入院的第三天,从血液培养物中分离出弯曲杆菌。患者接受美罗培南(MEPM)治疗,第17天出院。然而,他经历了脑膜炎的复发,并在第68天再次入院,启动MEPM治疗。第74天从脑脊液培养物中分离出胎儿弯曲杆菌。MEPM一直持续到第81天,随后一个月的米诺环素(MINO)治疗。患者恢复顺利,没有进一步复发。该病例强调了在最初感染消退约两个月后,弯曲杆菌胎儿脑膜炎复发的可能性。除了碳青霉烯治疗至少两周,MINO的辅助给药可能是有益的。
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