Abstract：
UNASSIGNED: The current study aims to evaluate the correlation between oxytocin augmentation and postpartum hemorrhage.
UNASSIGNED: PubMed, Web of Science, and Scopus has been searched for studies assessing the correlation between oxytocin augmentation and postpartum hemorrhage up to January 24, 2024. The search strategy included relevant keywords related to PPH and oxytocin augmentation. The risk of bias assessment was conducted by two reviewers using the Newcastle-Ottawa Scale (NOS). To pool the effects sized of included studies odds ratios (OR) of interest outcome with their 95% confidence interval (CI) were used.
UNASSIGNED: Eight studies were included in this meta-analysis. The pooled analysis of the included studies showed a statistically significant association between oxytocin augmentation and increased odds of PPH (pooled odds ratio [OR] = 1.27, 95% confidence interval [CI]: 1.05-1.53; I2 = 84.94%; p = 0.01). Publication bias was assessed using funnel plots, which appeared relatively asymmetrical, indicating significant publication bias. Galbraith plot and trim and fill plot were used for publication bias. Sensitivity analyses were performed by leave one out method.
UNASSIGNED: This meta-analysis suggests that using oxytocin for labor augmentation is linked to a significant increase in the risk of PPH. It highlights the need for careful monitoring and consideration when using oxytocin, especially in low and middle-income countries where guidelines and supervision are crucial.
UNASSIGNED: PubMed, Web of Science, and Scopus has been searched for studies assessing the correlation between oxytocin augmentation and postpartum hemorrhage up to January 24, 2024. The search strategy included relevant keywords related to PPH and oxytocin augmentation. The risk of bias assessment was conducted by two reviewers using the Newcastle-Ottawa Scale (NOS). To pool the effects sized of included studies odds ratios (OR) of interest outcome with their 95% confidence interval (CI) were used.
UNASSIGNED: Eight studies were included in this meta-analysis. The pooled analysis of the included studies showed a statistically significant association between oxytocin augmentation and increased odds of PPH (pooled odds ratio [OR] = 1.27, 95% confidence interval [CI]: 1.05-1.53; I2 = 84.94%; p = 0.01). Publication bias was assessed using funnel plots, which appeared relatively asymmetrical, indicating significant publication bias. Galbraith plot and trim and fill plot were used for publication bias. Sensitivity analyses were performed by leave one out method.
UNASSIGNED: This meta-analysis suggests that using oxytocin for labor augmentation is linked to a significant increase in the risk of PPH. It highlights the need for careful monitoring and consideration when using oxytocin, especially in low and middle-income countries where guidelines and supervision are crucial.
摘要：
■本研究旨在评估催产素增加与产后出血之间的相关性。
■PubMed,WebofScience,截至2024年1月24日，Scopus已经搜索了评估催产素增加与产后出血之间相关性的研究。搜索策略包括与PPH和催产素增强相关的相关关键词。偏见的风险评估是由两名审阅者使用纽卡斯尔-渥太华量表（NOS）进行的。为了汇集纳入研究的影响大小，使用了感兴趣结果的优势比（OR）及其95％置信区间（CI）。
■本荟萃分析包括8项研究。纳入研究的汇总分析显示，催产素增强与PPH几率增加之间存在统计学上的显着关联（汇总优势比[OR]=1.27，95％置信区间[CI]：1.05-1.53；I2=84.94％；p=0.01）。使用漏斗图评估出版偏倚，看起来相对不对称，表明显著的发表偏倚。Galbraith图和修剪和填充图用于出版偏见。敏感性分析采用留一法进行。
■这项荟萃分析表明，使用催产素进行分娩与PPH风险的显着增加有关。它强调了在使用催产素时需要仔细监测和考虑，特别是在指导和监督至关重要的中低收入国家。
■PubMed,WebofScience,截至2024年1月24日，Scopus已经搜索了评估催产素增加与产后出血之间相关性的研究。搜索策略包括与PPH和催产素增强相关的相关关键词。偏见的风险评估是由两名审阅者使用纽卡斯尔-渥太华量表（NOS）进行的。为了汇集纳入研究的影响大小，使用了感兴趣结果的优势比（OR）及其95％置信区间（CI）。
■本荟萃分析包括8项研究。纳入研究的汇总分析显示，催产素增强与PPH几率增加之间存在统计学上的显着关联（汇总优势比[OR]=1.27，95％置信区间[CI]：1.05-1.53；I2=84.94％；p=0.01）。使用漏斗图评估出版偏倚，看起来相对不对称，表明显著的发表偏倚。Galbraith图和修剪和填充图用于出版偏见。敏感性分析采用留一法进行。
■这项荟萃分析表明，使用催产素进行分娩与PPH风险的显着增加有关。它强调了在使用催产素时需要仔细监测和考虑，特别是在指导和监督至关重要的中低收入国家。
