Abstract：
BACKGROUND: The International Atherosclerosis Society (IAS) published an evidence-informed guidance for familial hypercholesterolemia (FH) that provides both clinical and implementation recommendations. We reference examples of strategies from the literature to explore how these implementation recommendations can be tailored into implementation strategies at the local-level for stakeholders guided by a framework proposed by Sarkies and Jones.
METHODS: Four authors of the IAS guidance selected two published exemplar implementation recommendations for detection, management, and general implementation. Each recommendation was described as an implementation strategy using Proctor\'s guidance for specifying and reporting implementation strategies. It recommends reporting the actor (who), action (what), action-target (who is impacted), temporality (how often), and dose (how much) for each implementation strategy.
RESULTS: Detection: A centralized cascade testing model, mobilized nurses (actor) to relative\'s homes, after the diagnosis of the proband (temporality), once (dose) to consent, obtain a blood sample and health information (action) on relatives (action-target).
RESULTS: A primary care initiative to improve FH management included an educational session (action) with clinicians (action-target), computer-based reminder message and message to patients to have their cholesterol screened once (dose) at a visit or outreach (temporality) by researchers (actor). General: A partnership between a statewide public pathology provider, local public hospital network, primary health network, government health ministry, and an academic university (actors) was established to implement a primary-tertiary shared care model (action) to improve the detection of FH (action-target).
CONCLUSIONS: We demonstrate that implementation recommendations can be specified and reported for different local contexts with examples on monitoring, evaluation, and sustainability in practice.
METHODS: Four authors of the IAS guidance selected two published exemplar implementation recommendations for detection, management, and general implementation. Each recommendation was described as an implementation strategy using Proctor\'s guidance for specifying and reporting implementation strategies. It recommends reporting the actor (who), action (what), action-target (who is impacted), temporality (how often), and dose (how much) for each implementation strategy.
RESULTS: Detection: A centralized cascade testing model, mobilized nurses (actor) to relative\'s homes, after the diagnosis of the proband (temporality), once (dose) to consent, obtain a blood sample and health information (action) on relatives (action-target).
RESULTS: A primary care initiative to improve FH management included an educational session (action) with clinicians (action-target), computer-based reminder message and message to patients to have their cholesterol screened once (dose) at a visit or outreach (temporality) by researchers (actor). General: A partnership between a statewide public pathology provider, local public hospital network, primary health network, government health ministry, and an academic university (actors) was established to implement a primary-tertiary shared care model (action) to improve the detection of FH (action-target).
CONCLUSIONS: We demonstrate that implementation recommendations can be specified and reported for different local contexts with examples on monitoring, evaluation, and sustainability in practice.
摘要：
背景：国际动脉粥样硬化协会（IAS）发表了关于家族性高胆固醇血症（FH）的循证指南，提供了临床和实施建议。我们参考了文献中的策略示例，以探讨如何在Sarkies和Jones提出的框架的指导下，将这些实施建议调整为地方一级的利益相关者的实施策略。
方法：IAS指南的四位作者选择了两个已发布的示例性实施建议进行检测，管理,和一般实施。使用Proctor的指导来指定和报告实施策略，将每个建议描述为实施策略。它建议报告演员（谁），行动（什么），行动目标(受影响的人)，时间性（多久），以及每个实施策略的剂量(多少)。
结果：检测：集中式级联测试模型，动员护士(演员)到亲戚家里，在先证者(时间性)诊断后，一次（剂量）同意，获取亲属的血液样本和健康信息（行动）（行动目标）。
结果：改善FH管理的初级保健计划包括与临床医生（行动目标）的教育会议（行动），基于计算机的提醒信息和信息给患者，让他们的胆固醇筛查一次（剂量）在访问或外展（时间性）由研究人员（演员）。一般：全州公共病理学提供者之间的伙伴关系，当地公立医院网络，初级卫生网络，政府卫生部,并建立了一所学术大学（参与者），以实施初级-三级共享护理模式（行动），以改善FH（行动目标）的检测。
结论：我们证明了可以针对不同的地方环境指定和报告实施建议，并举例说明监测，评估，在实践中的可持续性。
方法：IAS指南的四位作者选择了两个已发布的示例性实施建议进行检测，管理,和一般实施。使用Proctor的指导来指定和报告实施策略，将每个建议描述为实施策略。它建议报告演员（谁），行动（什么），行动目标(受影响的人)，时间性（多久），以及每个实施策略的剂量(多少)。
结果：检测：集中式级联测试模型，动员护士(演员)到亲戚家里，在先证者(时间性)诊断后，一次（剂量）同意，获取亲属的血液样本和健康信息（行动）（行动目标）。
结果：改善FH管理的初级保健计划包括与临床医生（行动目标）的教育会议（行动），基于计算机的提醒信息和信息给患者，让他们的胆固醇筛查一次（剂量）在访问或外展（时间性）由研究人员（演员）。一般：全州公共病理学提供者之间的伙伴关系，当地公立医院网络，初级卫生网络，政府卫生部,并建立了一所学术大学（参与者），以实施初级-三级共享护理模式（行动），以改善FH（行动目标）的检测。
结论：我们证明了可以针对不同的地方环境指定和报告实施建议，并举例说明监测，评估，在实践中的可持续性。
