METHODS: This study will use a three-arm randomised controlled trial design to compare the effectiveness and cost-effectiveness of text message reminders and PN to increase the uptake of bowel cancer screening in London. Participants will be individuals who have not returned a completed faecal immunochemical test kit within 13 weeks of receiving a routine invitation from the London bowel cancer screening hub. Participants will be randomised (in a 1:1:1 ratio) to receive either (1) usual care (ie, \'no intervention\'), (2) a text message reminder at 13 weeks, followed by repeated text message reminders at 15, 17 and 19 weeks (in the event of non-response) or (3) a text message reminder at 13 weeks, followed by PN telephone calls at 15, 17 and 19 weeks in the event of non-response. The primary endpoint will be participation in bowel cancer screening, defined as \'the return of a completed kit by week 24\'. Statistical analysis will use multivariate logistic regression and will incorporate pairwise comparisons of all three groups, adjusted for multiple testing.
BACKGROUND: Approvals to conduct the research have been obtained from University College London\'s Joint Research Office (Ref: 150666), the Screening Research, Innovation and Development Advisory Committee (\'RIDAC\', Ref: 2223 014 BCSP Kerrison), the Health Research Authority (Ref: 22/WM/0212) and the Confidentiality Advisory Group (Ref: 22/CAG/0140). Results will be conveyed to stakeholders, notably those managing the screening programme and published in peer-reviewed journals/presented at academic conferences.
BACKGROUND: ISRCTN17245519.
方法:本研究将使用三臂随机对照试验设计来比较短信提醒和PN的有效性和成本效益,以增加伦敦对肠癌筛查的吸收。参与者将是在收到伦敦肠癌筛查中心的常规邀请后13周内尚未返回完整的粪便免疫化学检测试剂盒的个人。参与者将被随机(以1:1:1的比例)接受(1)常规护理(即,\'无干预\'),(2)短信提醒在13周,随后在15、17和19周重复短信提醒(如果没有反应)或(3)在13周时短信提醒,随后在15、17和19周时进行PN电话呼叫,以防无反应。主要终点将是参与肠癌筛查,定义为“在第24周之前归还已完成的工具包”。统计分析将使用多变量逻辑回归,并将纳入所有三组的成对比较,针对多次测试进行了调整。
背景:已获得伦敦大学学院联合研究办公室的批准(编号:150666),筛查研究,创新与发展咨询委员会(“RIDAC”,Ref:2223014BCSPKerrison),卫生研究机构(编号:22/WM/0212)和保密咨询小组(编号:22/CAG/0140)。结果将传达给利益相关者,特别是那些管理筛查计划并在同行评审期刊上发表/在学术会议上发表的人。
背景:ISRCTN17245519。