Abstract：
BACKGROUND: Participation in bowel cancer screening is lower in regions where there is high ethnic diversity and/or socioeconomic deprivation. Interventions, such as text message reminders and patient navigation (PN), have the potential to increase participation in these areas. As such, there is interest in the comparative effectiveness of these interventions to increase bowel cancer screening participation, as well as their relative cost-effectiveness.
METHODS: This study will use a three-arm randomised controlled trial design to compare the effectiveness and cost-effectiveness of text message reminders and PN to increase the uptake of bowel cancer screening in London. Participants will be individuals who have not returned a completed faecal immunochemical test kit within 13 weeks of receiving a routine invitation from the London bowel cancer screening hub. Participants will be randomised (in a 1:1:1 ratio) to receive either (1) usual care (ie, \'no intervention\'), (2) a text message reminder at 13 weeks, followed by repeated text message reminders at 15, 17 and 19 weeks (in the event of non-response) or (3) a text message reminder at 13 weeks, followed by PN telephone calls at 15, 17 and 19 weeks in the event of non-response. The primary endpoint will be participation in bowel cancer screening, defined as \'the return of a completed kit by week 24\'. Statistical analysis will use multivariate logistic regression and will incorporate pairwise comparisons of all three groups, adjusted for multiple testing.
BACKGROUND: Approvals to conduct the research have been obtained from University College London\'s Joint Research Office (Ref: 150666), the Screening Research, Innovation and Development Advisory Committee (\'RIDAC\', Ref: 2223 014 BCSP Kerrison), the Health Research Authority (Ref: 22/WM/0212) and the Confidentiality Advisory Group (Ref: 22/CAG/0140). Results will be conveyed to stakeholders, notably those managing the screening programme and published in peer-reviewed journals/presented at academic conferences.
BACKGROUND: ISRCTN17245519.
METHODS: This study will use a three-arm randomised controlled trial design to compare the effectiveness and cost-effectiveness of text message reminders and PN to increase the uptake of bowel cancer screening in London. Participants will be individuals who have not returned a completed faecal immunochemical test kit within 13 weeks of receiving a routine invitation from the London bowel cancer screening hub. Participants will be randomised (in a 1:1:1 ratio) to receive either (1) usual care (ie, \'no intervention\'), (2) a text message reminder at 13 weeks, followed by repeated text message reminders at 15, 17 and 19 weeks (in the event of non-response) or (3) a text message reminder at 13 weeks, followed by PN telephone calls at 15, 17 and 19 weeks in the event of non-response. The primary endpoint will be participation in bowel cancer screening, defined as \'the return of a completed kit by week 24\'. Statistical analysis will use multivariate logistic regression and will incorporate pairwise comparisons of all three groups, adjusted for multiple testing.
BACKGROUND: Approvals to conduct the research have been obtained from University College London\'s Joint Research Office (Ref: 150666), the Screening Research, Innovation and Development Advisory Committee (\'RIDAC\', Ref: 2223 014 BCSP Kerrison), the Health Research Authority (Ref: 22/WM/0212) and the Confidentiality Advisory Group (Ref: 22/CAG/0140). Results will be conveyed to stakeholders, notably those managing the screening programme and published in peer-reviewed journals/presented at academic conferences.
BACKGROUND: ISRCTN17245519.
摘要：
背景：在种族多样性和/或社会经济匮乏的地区，参与肠癌筛查的程度较低。干预措施,如短信提醒和患者导航(PN)，有可能增加这些领域的参与。因此，人们对这些干预措施在增加肠癌筛查参与方面的相对有效性感兴趣，以及它们的相对成本效益。
方法：本研究将使用三臂随机对照试验设计来比较短信提醒和PN的有效性和成本效益，以增加伦敦对肠癌筛查的吸收。参与者将是在收到伦敦肠癌筛查中心的常规邀请后13周内尚未返回完整的粪便免疫化学检测试剂盒的个人。参与者将被随机（以1：1：1的比例）接受（1）常规护理（即，\'无干预\'),（2）短信提醒在13周，随后在15、17和19周重复短信提醒(如果没有反应)或(3)在13周时短信提醒,随后在15、17和19周时进行PN电话呼叫，以防无反应。主要终点将是参与肠癌筛查，定义为“在第24周之前归还已完成的工具包”。统计分析将使用多变量逻辑回归，并将纳入所有三组的成对比较，针对多次测试进行了调整。
背景：已获得伦敦大学学院联合研究办公室的批准（编号：150666），筛查研究，创新与发展咨询委员会(“RIDAC”，Ref:2223014BCSPKerrison),卫生研究机构（编号：22/WM/0212）和保密咨询小组（编号：22/CAG/0140）。结果将传达给利益相关者，特别是那些管理筛查计划并在同行评审期刊上发表/在学术会议上发表的人。
背景：ISRCTN17245519。
方法：本研究将使用三臂随机对照试验设计来比较短信提醒和PN的有效性和成本效益，以增加伦敦对肠癌筛查的吸收。参与者将是在收到伦敦肠癌筛查中心的常规邀请后13周内尚未返回完整的粪便免疫化学检测试剂盒的个人。参与者将被随机（以1：1：1的比例）接受（1）常规护理（即，\'无干预\'),（2）短信提醒在13周，随后在15、17和19周重复短信提醒(如果没有反应)或(3)在13周时短信提醒,随后在15、17和19周时进行PN电话呼叫，以防无反应。主要终点将是参与肠癌筛查，定义为“在第24周之前归还已完成的工具包”。统计分析将使用多变量逻辑回归，并将纳入所有三组的成对比较，针对多次测试进行了调整。
背景：已获得伦敦大学学院联合研究办公室的批准（编号：150666），筛查研究，创新与发展咨询委员会(“RIDAC”，Ref:2223014BCSPKerrison),卫生研究机构（编号：22/WM/0212）和保密咨询小组（编号：22/CAG/0140）。结果将传达给利益相关者，特别是那些管理筛查计划并在同行评审期刊上发表/在学术会议上发表的人。
背景：ISRCTN17245519。
