Abstract：
BACKGROUND: Previous task-related functional magnetic resonance imaging (task-fMRI) investigations have documented abnormal brain activation associated with subclinical depression (SD), defined as a clinically relevant level of depressive symptoms that does not meet the diagnostic criteria for major depressive disorder. However, these task-fMRI studies have not reported consistent conclusions. Performing a voxel-based meta-analysis of task-fMRI studies may yield reliable findings.
METHODS: We extracted the peak coordinates and t values of included studies and analyzed brain activation between individuals with SD and healthy controls (HCs) using anisotropic effect-size signed differential mapping (AES-SDM).
RESULTS: A systematic literature search identified eight studies, including 266 individuals with SD and 281 HCs (aged 14 to 25). The meta-analysis showed that individuals with SD exhibited significantly greater activation in the right lenticular nucleus and putamen according to task-fMRI. The meta-regression analysis revealed a negative correlation between the proportion of females in a group and activation in the right striatum.
CONCLUSIONS: The recruitment criteria for individuals with SD, type of tasks and MRI acquisition parameters of included studies were heterogeneous. The results should be interpreted cautiously due to insufficient included studies.
CONCLUSIONS: Our findings suggest that individuals with SD exhibit increased activation in the right lenticular nucleus, putamen and striatum, which may indicate a compensatory increase in response to an impairment of insular and striatal function caused by depression. These results provide valuable insights into the potential pathophysiology of brain dysfunction in SD.
METHODS: We extracted the peak coordinates and t values of included studies and analyzed brain activation between individuals with SD and healthy controls (HCs) using anisotropic effect-size signed differential mapping (AES-SDM).
RESULTS: A systematic literature search identified eight studies, including 266 individuals with SD and 281 HCs (aged 14 to 25). The meta-analysis showed that individuals with SD exhibited significantly greater activation in the right lenticular nucleus and putamen according to task-fMRI. The meta-regression analysis revealed a negative correlation between the proportion of females in a group and activation in the right striatum.
CONCLUSIONS: The recruitment criteria for individuals with SD, type of tasks and MRI acquisition parameters of included studies were heterogeneous. The results should be interpreted cautiously due to insufficient included studies.
CONCLUSIONS: Our findings suggest that individuals with SD exhibit increased activation in the right lenticular nucleus, putamen and striatum, which may indicate a compensatory increase in response to an impairment of insular and striatal function caused by depression. These results provide valuable insights into the potential pathophysiology of brain dysfunction in SD.
摘要：
背景：先前的任务相关功能磁共振成像（task-fMRI）研究已证明与亚临床抑郁症（SD）相关的异常大脑激活，定义为不符合重度抑郁障碍诊断标准的抑郁症状的临床相关水平。然而,这些task-fMRI研究没有报告一致的结论.对任务功能磁共振成像研究进行基于体素的荟萃分析可能会产生可靠的发现。
方法：我们提取了纳入研究的峰坐标和t值，并使用各向异性效应-大小符号差分映射（AES-SDM）分析了SD个体和健康对照（HC）之间的大脑激活。
结果：系统的文献检索确定了8项研究，包括266名SD患者和281名HCs（年龄14至25岁）。荟萃分析显示，根据task-fMRI，患有SD的个体在右豆状核和壳核中表现出明显更大的激活。荟萃回归分析显示，一组中女性的比例与右纹状体的激活呈负相关。
结论：SD患者的招募标准，纳入研究的任务类型和MRI采集参数具有异质性.由于纳入的研究不足，应谨慎解释结果。
结论：我们的研究结果表明，患有SD的个体在右侧透镜状核的激活增加，壳核和纹状体，这可能表明对抑郁症引起的岛叶和纹状体功能受损的补偿性增加。这些结果为SD中脑功能障碍的潜在病理生理学提供了有价值的见解。
方法：我们提取了纳入研究的峰坐标和t值，并使用各向异性效应-大小符号差分映射（AES-SDM）分析了SD个体和健康对照（HC）之间的大脑激活。
结果：系统的文献检索确定了8项研究，包括266名SD患者和281名HCs（年龄14至25岁）。荟萃分析显示，根据task-fMRI，患有SD的个体在右豆状核和壳核中表现出明显更大的激活。荟萃回归分析显示，一组中女性的比例与右纹状体的激活呈负相关。
结论：SD患者的招募标准，纳入研究的任务类型和MRI采集参数具有异质性.由于纳入的研究不足，应谨慎解释结果。
结论：我们的研究结果表明，患有SD的个体在右侧透镜状核的激活增加，壳核和纹状体，这可能表明对抑郁症引起的岛叶和纹状体功能受损的补偿性增加。这些结果为SD中脑功能障碍的潜在病理生理学提供了有价值的见解。
