Abstract：
OBJECTIVE: Hemolytic transfusion reactions (HTRs) pose significant risks in transfused patients, with anti-A and anti-B antibodies in donor plasma being potential contributing factors. Despite advancements in component preparation, HTRs remain a concern, particularly with apheresis-derived platelets. This study aimed to determine the prevalence of high anti-A and anti-B titers among A, B, and O blood group donors and to explore factors associated with high titers.
METHODS: A cross-sectional observational study was conducted over 18 months, enrolling 978 participants from a tertiary care teaching hospital in Western India. Anti-A and anti-B titers were determined using the Conventional Tube Technique (CTT). Statistical analysis assessed correlations between high titers and demographic factors.
RESULTS: The majority of participants were young males (98.8%). Prevalence of high titers for IgM anti-A was 12.2% and IgG anti-A was 2.5%. For anti-B, IgM titers were 2.3% and IgG titers were 0.2%. The prevalence of dangerous O was found to be 14.1%, while 3.52% and 10.5% of A and B blood group donors were found to have high titers, respectively. Factors associated with high titers included female gender, vegetarian diet, age <30 years, and O blood group.
CONCLUSIONS: The study sheds additional light and provides supplementary information regarding the prevalence and correlation of high anti-A and anti-B titers among O, A and B blood donors. Understanding these factors is crucial for optimizing transfusion safety protocols, including selective screening of platelet units and tailored transfusion strategies based on donor characteristics.
METHODS: A cross-sectional observational study was conducted over 18 months, enrolling 978 participants from a tertiary care teaching hospital in Western India. Anti-A and anti-B titers were determined using the Conventional Tube Technique (CTT). Statistical analysis assessed correlations between high titers and demographic factors.
RESULTS: The majority of participants were young males (98.8%). Prevalence of high titers for IgM anti-A was 12.2% and IgG anti-A was 2.5%. For anti-B, IgM titers were 2.3% and IgG titers were 0.2%. The prevalence of dangerous O was found to be 14.1%, while 3.52% and 10.5% of A and B blood group donors were found to have high titers, respectively. Factors associated with high titers included female gender, vegetarian diet, age <30 years, and O blood group.
CONCLUSIONS: The study sheds additional light and provides supplementary information regarding the prevalence and correlation of high anti-A and anti-B titers among O, A and B blood donors. Understanding these factors is crucial for optimizing transfusion safety protocols, including selective screening of platelet units and tailored transfusion strategies based on donor characteristics.
摘要：
目的：溶血性输血反应（HTRs）对输血患者构成重大风险，供体血浆中的抗A和抗B抗体是潜在的促成因素。尽管在组件准备方面取得了进步，HTRs仍然是一个令人担忧的问题，特别是单采血小板。这项研究旨在确定高抗A和抗B滴度的患病率，B,和O血型献血者，并探讨与高滴度相关的因素。
方法：进行了为期18个月的横断面观察研究，从印度西部的三级护理教学医院招募978名参与者。使用常规管技术(CTT)测定抗A和抗B滴度。统计分析评估了高滴度与人口统计学因素之间的相关性。
结果：大多数参与者是年轻男性（98.8%）。高滴度的IgM抗-A的患病率为12.2%,IgG抗-A为2.5%。对于反B，IgM滴度为2.3%,IgG滴度为0.2%。发现危险O的患病率为14.1%，而3.52%和10.5%的A和B血型献血者被发现具有高滴度，分别。与高滴度相关的因素包括女性，素食,年龄<30岁，和O血型。
结论：该研究揭示了更多的信息，并提供了有关O，A和B献血者。了解这些因素对于优化输血安全方案至关重要，包括选择性筛选血小板单位和根据供者特征定制的输血策略。
方法：进行了为期18个月的横断面观察研究，从印度西部的三级护理教学医院招募978名参与者。使用常规管技术(CTT)测定抗A和抗B滴度。统计分析评估了高滴度与人口统计学因素之间的相关性。
结果：大多数参与者是年轻男性（98.8%）。高滴度的IgM抗-A的患病率为12.2%,IgG抗-A为2.5%。对于反B，IgM滴度为2.3%,IgG滴度为0.2%。发现危险O的患病率为14.1%，而3.52%和10.5%的A和B血型献血者被发现具有高滴度，分别。与高滴度相关的因素包括女性，素食,年龄<30岁，和O血型。
结论：该研究揭示了更多的信息，并提供了有关O，A和B献血者。了解这些因素对于优化输血安全方案至关重要，包括选择性筛选血小板单位和根据供者特征定制的输血策略。
