{Reference Type}: Journal Article
{Title}: Anti-A and anti-B titers in A, B and O whole blood donors: Beyond "dangerous O".
{Author}: Chatterjee AK;Kaur P;Bava D;Gupta A;Kumar A;Kumar R;
{Journal}: Transfus Clin Biol
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jun 21
{Factor}: 2.126
{DOI}: 10.1016/j.tracli.2024.06.007
{Abstract}: <B>OBJECTIVE: </B>Hemolytic transfusion reactions (HTRs) pose significant risks in transfused patients, with anti-A and anti-B antibodies in donor plasma being potential contributing factors. Despite advancements in component preparation, HTRs remain a concern, particularly with apheresis-derived platelets. This study aimed to determine the prevalence of high anti-A and anti-B titers among A, B, and O blood group donors and to explore factors associated with high titers.<BR><B>METHODS: </B>A cross-sectional observational study was conducted over 18 months, enrolling 978 participants from a tertiary care teaching hospital in Western India. Anti-A and anti-B titers were determined using the Conventional Tube Technique (CTT). Statistical analysis assessed correlations between high titers and demographic factors.<BR><B>RESULTS: </B>The majority of participants were young males (98.8%). Prevalence of high titers for IgM anti-A was 12.2% and IgG anti-A was 2.5%. For anti-B, IgM titers were 2.3% and IgG titers were 0.2%. The prevalence of dangerous O was found to be 14.1%, while 3.52% and 10.5% of A and B blood group donors were found to have high titers, respectively. Factors associated with high titers included female gender, vegetarian diet, age <30 years, and O blood group.<BR><B>CONCLUSIONS: </B>The study sheds additional light and provides supplementary information regarding the prevalence and correlation of high anti-A and anti-B titers among O, A and B blood donors. Understanding these factors is crucial for optimizing transfusion safety protocols, including selective screening of platelet units and tailored transfusion strategies based on donor characteristics.