Abstract：
Primary Sjögren syndrome (pSS) is a systemic autoimmune disorder that affects various systems in the body, resulting in symptoms such as dry eyes and mouth, pain, and fatigue. Inflammation plays a critical role in pSS and its associated complications, with chronic inflammation being a common occurrence in patients with pSS. This review of the literature highlights inflammatory markers that could serve as indicators to predict disease progression in pSS. Laboratory markers are frequently and significantly increased in pSS patients, including erythrocyte sedimentation rate, C-reactive protein, complement proteins, S100 proteins, cytokines (IFNs, CD40 ligand, soluble CD25, rheumatoid factors, interleukins, and TNF-α), and chemokines (CXCL13, CXCL10, CCL2, CXCL11, and CCL25). These inflammatory markers can be used as prognostic indicators for disease progression in pSS. In conclusion, the results from the studies reported in this review indicate that high levels of inflammatory markers may serve as markers for disease progression of pSS, which, in turn, may be valuable in predicting disease outcome.
摘要：
原发性干燥综合征（pSS）是一种全身性自身免疫性疾病，会影响体内的各个系统，导致眼睛和口腔干涩等症状，疼痛,和疲劳。炎症在pSS及其相关并发症中起关键作用，慢性炎症在pSS患者中很常见。这篇文献综述强调了可以作为预测pSS疾病进展的指标的炎症标志物。pSS患者的实验室标志物频繁且显著增加，包括红细胞沉降率，C反应蛋白,补体蛋白，S100蛋白,细胞因子(IFNs，CD40配体，可溶性CD25，类风湿因子，白细胞介素,和TNF-α），和趋化因子(CXCL13、CXCL10、CCL2、CXCL11和CCL25)。这些炎性标志物可用作pSS中疾病进展的预后指标。总之,本综述中报道的研究结果表明，高水平的炎症标志物可能作为pSS疾病进展的标志物，which,反过来,可能是有价值的预测疾病的结果。
