PDF(Pubmed)
Abstract：
BACKGROUND: Currently, several studies have observed that chronic hepatitis B virus infection is associated with the pathogenesis of kidney disease. However, the extent of the correlation between hepatitis B virus infection and the chronic kidney disease risk remains controversial.
METHODS: In the present study, we searched all eligible literature in seven databases in English and Chinese. The random effects model was used to conduct a meta-analysis. Quality of included studies was assessed using the Newcastle-Ottawa Quality Scale.
RESULTS: In this analysis, a total of 31 studies reporting the association between hepatitis B virus infection and chronic kidney disease risk were included. The results showed a significant positive association between hepatitis B virus infection and the risk of chronic kidney disease (pooled OR, 1.20; 95% CI, 1.12-1.29), which means that hepatitis B virus increases the risk of developing chronic kidney disease.
CONCLUSIONS: This study found that hepatitis B virus infection was associated with a significantly increased risk of chronic kidney disease. However, the current study still cannot directly determine this causal relationship. Thus, more comprehensive prospective longitudinal studies are needed in the future to provide further exploration and explanation of the association between hepatitis B virus and the risk of developing chronic kidney disease.
METHODS: In the present study, we searched all eligible literature in seven databases in English and Chinese. The random effects model was used to conduct a meta-analysis. Quality of included studies was assessed using the Newcastle-Ottawa Quality Scale.
RESULTS: In this analysis, a total of 31 studies reporting the association between hepatitis B virus infection and chronic kidney disease risk were included. The results showed a significant positive association between hepatitis B virus infection and the risk of chronic kidney disease (pooled OR, 1.20; 95% CI, 1.12-1.29), which means that hepatitis B virus increases the risk of developing chronic kidney disease.
CONCLUSIONS: This study found that hepatitis B virus infection was associated with a significantly increased risk of chronic kidney disease. However, the current study still cannot directly determine this causal relationship. Thus, more comprehensive prospective longitudinal studies are needed in the future to provide further exploration and explanation of the association between hepatitis B virus and the risk of developing chronic kidney disease.
摘要：
背景：目前，多项研究表明，慢性乙型肝炎病毒感染与肾脏疾病的发病机制有关。然而,乙型肝炎病毒感染与慢性肾脏病风险之间的相关性仍存在争议.
方法：在本研究中，我们在七个中英文数据库中检索了所有符合条件的文献。采用随机效应模型进行Meta分析。使用纽卡斯尔-渥太华质量量表评估纳入研究的质量。
结果：在此分析中，共有31项研究报告了乙型肝炎病毒感染与慢性肾脏病风险之间的相关性.结果显示，乙型肝炎病毒感染与慢性肾脏病风险之间存在显着正相关（合并OR，1.20；95%CI，1.12-1.29），这意味着乙型肝炎病毒会增加患慢性肾脏疾病的风险。
结论：这项研究发现，乙型肝炎病毒感染与慢性肾脏疾病的风险明显增加有关。然而,目前的研究仍然不能直接确定这种因果关系。因此，未来需要更全面的前瞻性纵向研究来进一步探索和解释乙型肝炎病毒与慢性肾脏病发病风险之间的关系.
方法：在本研究中，我们在七个中英文数据库中检索了所有符合条件的文献。采用随机效应模型进行Meta分析。使用纽卡斯尔-渥太华质量量表评估纳入研究的质量。
结果：在此分析中，共有31项研究报告了乙型肝炎病毒感染与慢性肾脏病风险之间的相关性.结果显示，乙型肝炎病毒感染与慢性肾脏病风险之间存在显着正相关（合并OR，1.20；95%CI，1.12-1.29），这意味着乙型肝炎病毒会增加患慢性肾脏疾病的风险。
结论：这项研究发现，乙型肝炎病毒感染与慢性肾脏疾病的风险明显增加有关。然而,目前的研究仍然不能直接确定这种因果关系。因此，未来需要更全面的前瞻性纵向研究来进一步探索和解释乙型肝炎病毒与慢性肾脏病发病风险之间的关系.
