PDF(Pubmed)
Abstract：
Psychedelics have experienced renewed interest following positive clinical effects, however the neurobiological mechanisms underlying effects remain unclear. The paraventricular nucleus of the hypothalamus (PVN) plays an integral role in stress response, autonomic function, social behavior, and other affective processes. We investigated the effect of psilocin, the psychoactive metabolite of psilocybin, on PVN reactivity in Sprague Dawley rats. Psilocin increased stimulus-independent PVN activity as measured by c-Fos expression in male and female rats. Psilocin increased PVN reactivity to an aversive air-puff stimulus in males but not females. Reactivity was restored at 2- and 7-days post-injection with no group differences. Additionally, prior psilocin injection did not affect PVN reactivity following acute restraint stress. Experimental groups sub-classified by baseline threat responding indicate that increased male PVN reactivity is driven by active threat responders. These findings identify the PVN as a significant site of psychedelic drug action with implications for threat responding behavior.
摘要：
迷幻药在积极的临床效果后经历了新的兴趣，然而,潜在效应的神经生物学机制仍不清楚.下丘脑室旁核（PVN）在应激反应中起着不可或缺的作用，自主神经功能,社会行为,和其他情感过程。我们研究了psilocin的作用，psilocybin的精神活性代谢产物，SpragueDawley大鼠PVN反应性的研究。通过c-Fos表达在雄性和雌性大鼠中测量，Psilocin增加了不依赖刺激的PVN活性。Psilocin增加了男性而不是女性的PVN对厌恶性空气刺激的反应性。在注射后2天和7天恢复反应性,没有组差异。此外,先前注射psilocin不会影响急性束缚应激后的PVN反应性。通过基线威胁响应进行分类的实验组表明，男性PVN反应性的增加是由主动威胁响应者驱动的。这些发现将PVN确定为迷幻药作用的重要部位，并暗示了威胁响应行为。
