METHODS: In a cross-sectional study, 48 outpatients (28/20 men/women; 35 ± 11(SD) years) with schizophrenia spectrum disorders (ICD-10; F20-25) were administered the UCSD Performance-based Skills Assessment-Brief (UPSA-B; functional skills), Specific Level of Functioning (SLOF; functional performance) and the Positive and Negative Syndrome (PANSS) scale. Peak oxygen uptake (V̇O2peak) was assessed along with leg press maximal muscle strength (1RM) and mechanical power.
RESULTS: UPSA-B performance was associated with V̇O2peak (r = 0.28,p < 0.05), accounting for 8 % (p < 0.05) of shared variance, but was unrelated to 1RM and mechanical power. The SLOF physical functioning domain was associated with V̇O2peak (r = 0.30,p < 0.05) and 1RM (r = 0.24,p < 0.05), while SLOF personal care (r = 0.27,p < 0.05) and activities (r = 0.30,p < 0.05) were related only to V̇O2peak. Hierarchical regression analyses revealed that while V̇O2peak and age combined to account for 20 % (p < 0.05) of the variance in physical functioning, the contribution of 1RM was eliminated after adjusting for age. V̇O2peak and negative symptoms combined predicted 24 % and 35 % of the variance in personal care and activities, respectively. UPSA-B scores did not add to the prediction of SLOF scores.
CONCLUSIONS: Although V̇O2peak and 1RM both relate to functional outcomes, the combination of V̇O2peak, age, and negative symptoms exert the greatest detrimental influence on functional performance beyond skills deficits.
方法:在一项横断面研究中,对48名患有精神分裂症谱系障碍(ICD-10;F20-25)的门诊患者(男性/女性28/20;35±11(SD)岁)进行了UCSD基于绩效的技能评估简介(UPSA-B;功能技能),特定功能水平(SLOF;功能表现)和阳性和阴性综合征(PANSS)量表。评估峰值摄氧量(V²O2peak)以及腿部按压最大肌肉力量(1RM)和机械动力。
结果:UPSA-B性能与VäO2peak相关(r=0.28,p<0.05),占8%(p<0.05)的共享方差,但与1RM和机械动力无关。SLOF功能结构域与V
结论:尽管V²O2peak和1RM都与功能结果有关,的组合V♪O2peak,年龄,负面症状对功能表现的影响最大,而不是技能缺陷。