Abstract：
BACKGROUND: Patients with schizophrenia suffer from physical health conditions, culminating in reduced physical functioning with enormous costs for patients and society. Although aerobic endurance and skeletal muscle strength, typically reduced in this population, relate to cognition and function, no study has explored their respective contributions to performance of functional skills and everyday tasks.
METHODS: In a cross-sectional study, 48 outpatients (28/20 men/women; 35 ± 11(SD) years) with schizophrenia spectrum disorders (ICD-10; F20-25) were administered the UCSD Performance-based Skills Assessment-Brief (UPSA-B; functional skills), Specific Level of Functioning (SLOF; functional performance) and the Positive and Negative Syndrome (PANSS) scale. Peak oxygen uptake (V̇O2peak) was assessed along with leg press maximal muscle strength (1RM) and mechanical power.
RESULTS: UPSA-B performance was associated with V̇O2peak (r = 0.28,p < 0.05), accounting for 8 % (p < 0.05) of shared variance, but was unrelated to 1RM and mechanical power. The SLOF physical functioning domain was associated with V̇O2peak (r = 0.30,p < 0.05) and 1RM (r = 0.24,p < 0.05), while SLOF personal care (r = 0.27,p < 0.05) and activities (r = 0.30,p < 0.05) were related only to V̇O2peak. Hierarchical regression analyses revealed that while V̇O2peak and age combined to account for 20 % (p < 0.05) of the variance in physical functioning, the contribution of 1RM was eliminated after adjusting for age. V̇O2peak and negative symptoms combined predicted 24 % and 35 % of the variance in personal care and activities, respectively. UPSA-B scores did not add to the prediction of SLOF scores.
CONCLUSIONS: Although V̇O2peak and 1RM both relate to functional outcomes, the combination of V̇O2peak, age, and negative symptoms exert the greatest detrimental influence on functional performance beyond skills deficits.
METHODS: In a cross-sectional study, 48 outpatients (28/20 men/women; 35 ± 11(SD) years) with schizophrenia spectrum disorders (ICD-10; F20-25) were administered the UCSD Performance-based Skills Assessment-Brief (UPSA-B; functional skills), Specific Level of Functioning (SLOF; functional performance) and the Positive and Negative Syndrome (PANSS) scale. Peak oxygen uptake (V̇O2peak) was assessed along with leg press maximal muscle strength (1RM) and mechanical power.
RESULTS: UPSA-B performance was associated with V̇O2peak (r = 0.28,p < 0.05), accounting for 8 % (p < 0.05) of shared variance, but was unrelated to 1RM and mechanical power. The SLOF physical functioning domain was associated with V̇O2peak (r = 0.30,p < 0.05) and 1RM (r = 0.24,p < 0.05), while SLOF personal care (r = 0.27,p < 0.05) and activities (r = 0.30,p < 0.05) were related only to V̇O2peak. Hierarchical regression analyses revealed that while V̇O2peak and age combined to account for 20 % (p < 0.05) of the variance in physical functioning, the contribution of 1RM was eliminated after adjusting for age. V̇O2peak and negative symptoms combined predicted 24 % and 35 % of the variance in personal care and activities, respectively. UPSA-B scores did not add to the prediction of SLOF scores.
CONCLUSIONS: Although V̇O2peak and 1RM both relate to functional outcomes, the combination of V̇O2peak, age, and negative symptoms exert the greatest detrimental influence on functional performance beyond skills deficits.
摘要：
背景：精神分裂症患者患有身体健康状况，最终导致身体机能下降，给患者和社会带来巨大的成本。虽然有氧耐力和骨骼肌力量，通常在这个人口中减少，与认知和功能有关，没有研究探讨他们各自对功能技能和日常任务表现的贡献。
方法：在一项横断面研究中，对48名患有精神分裂症谱系障碍（ICD-10；F20-25）的门诊患者（男性/女性28/20；35±11（SD）岁）进行了UCSD基于绩效的技能评估简介（UPSA-B；功能技能），特定功能水平(SLOF;功能表现)和阳性和阴性综合征(PANSS)量表。评估峰值摄氧量（V²O2peak）以及腿部按压最大肌肉力量（1RM）和机械动力。
结果：UPSA-B性能与VäO2peak相关（r=0.28，p<0.05），占8%(p<0.05)的共享方差，但与1RM和机械动力无关。SLOF功能结构域与VO2峰(r=0.30,p<0.05)和1RM(r=0.24,p<0.05)相关,而SLOF个人护理（r=0.27，p<0.05）和活动（r=0.30，p<0.05）仅与V?O2峰相关。分层回归分析显示，虽然V²O2peak和年龄合计占身体机能差异的20％（p<0.05），调整年龄后，1RM的贡献被消除。O2peak和阴性症状联合预测个人护理和活动差异的24%和35%，分别。UPSA-B评分没有增加SLOF评分的预测。
结论：尽管V²O2peak和1RM都与功能结果有关，的组合V♪O2peak，年龄,负面症状对功能表现的影响最大，而不是技能缺陷。
方法：在一项横断面研究中，对48名患有精神分裂症谱系障碍（ICD-10；F20-25）的门诊患者（男性/女性28/20；35±11（SD）岁）进行了UCSD基于绩效的技能评估简介（UPSA-B；功能技能），特定功能水平(SLOF;功能表现)和阳性和阴性综合征(PANSS)量表。评估峰值摄氧量（V²O2peak）以及腿部按压最大肌肉力量（1RM）和机械动力。
结果：UPSA-B性能与VäO2peak相关（r=0.28，p<0.05），占8%(p<0.05)的共享方差，但与1RM和机械动力无关。SLOF功能结构域与V
结论：尽管V²O2peak和1RM都与功能结果有关，的组合V♪O2peak，年龄,负面症状对功能表现的影响最大，而不是技能缺陷。
