Abstract：
The rapid and accurate analysis of micro-samples is a crucial foundation for precision medicine, particularly for early screening and monitoring of cancer, where it holds significant importance. Ultrasound-based multifunctional biocompatible manipulation techniques have been extensively applied in a variety of biomedical fields, providing insights for the development of rapid, cost-effective, and accurate biomarker detection strategies. In this chapter, we combine ultrasound-based gradient pressure fields with functionalized microsphere enrichment to develop a biosensing method for ultra-trace miRNA enrichment in nanoliter samples without PCR. This system relies on inexpensive capillaries, enabling simultaneous visual imaging and trace sample detection.
摘要：
微量样品的快速准确分析是精准医疗的重要基础,特别是癌症的早期筛查和监测，在那里它具有显著的重要性。基于超声的多功能生物相容性操作技术已广泛应用于各种生物医学领域,为快速发展提供见解，成本效益高,和准确的生物标志物检测策略。在这一章中,我们将基于超声的梯度压力场与功能化微球富集相结合，开发了一种无需PCR即可在纳升样品中富集超痕量miRNA的生物传感方法。这个系统依赖于廉价的毛细血管，使同时视觉成像和痕量样品检测。
