Abstract：
OBJECTIVE: Chronic headaches are a significant source of disability worldwide. Despite the development of conventional strategies, a subset of patients remain refractory and/or experience side effects following these treatments. Hence, occipital nerve stimulation (ONS) should be considered as an alternative strategy for intractable chronic headaches. This review aims to provide a comprehensive overview of the effectiveness, safety, mechanisms and practical application of ONS for the treatment of headache disorders.
RESULTS: Overall response rate of ONS is 35.7-100%, 17-100%, and 63-100% in patients with cluster headache, chronic migraine and occipital neuralgia respectively. Regarding the long-term effectivity in all groups, 41.6-88.0% of patients remain responders after ≥ 18.3 months. The most frequently reported adverse events include lead migration/fracture (13%) and local pain (7.3%). Based on our results, ONS can be considered a safe and effective treatment for chronic intractable headache disorders. To support more widespread application of ONS, additional research with larger sample sizes should be conducted.
RESULTS: Overall response rate of ONS is 35.7-100%, 17-100%, and 63-100% in patients with cluster headache, chronic migraine and occipital neuralgia respectively. Regarding the long-term effectivity in all groups, 41.6-88.0% of patients remain responders after ≥ 18.3 months. The most frequently reported adverse events include lead migration/fracture (13%) and local pain (7.3%). Based on our results, ONS can be considered a safe and effective treatment for chronic intractable headache disorders. To support more widespread application of ONS, additional research with larger sample sizes should be conducted.
摘要：
目的：慢性头痛是全球残疾的重要来源。尽管发展了传统战略，一部分患者在这些治疗后仍然难治和/或出现副作用。因此，枕神经刺激（ONS）应被视为顽固性慢性头痛的替代策略。这篇综述旨在全面概述有效性，安全,ONS治疗头痛障碍的机制和实际应用。
结果：ONS的总体反应率为35.7-100％，17-100%,丛集性头痛患者的比例为63-100%，慢性偏头痛和枕神经痛。关于所有群体的长期有效性，41.6-88.0%的患者在≥18.3个月后仍然有反应。最常报告的不良事件包括导线迁移/断裂(13%)和局部疼痛(7.3%)。根据我们的结果,ONS可被认为是治疗慢性顽固性头痛的安全有效的方法。为了支持ONS更广泛的应用，应进行更大样本量的额外研究。
结果：ONS的总体反应率为35.7-100％，17-100%,丛集性头痛患者的比例为63-100%，慢性偏头痛和枕神经痛。关于所有群体的长期有效性，41.6-88.0%的患者在≥18.3个月后仍然有反应。最常报告的不良事件包括导线迁移/断裂(13%)和局部疼痛(7.3%)。根据我们的结果,ONS可被认为是治疗慢性顽固性头痛的安全有效的方法。为了支持ONS更广泛的应用，应进行更大样本量的额外研究。
