{Reference Type}: Journal Article
{Title}: Four Decades of Occipital Nerve Stimulation for Headache Disorders: A Systematic Review.
{Author}: Kollenburg L;Kurt E;Mulleners W;Abd-Elsayed A;Yazdi C;Schatman ME;Yong RJ;Cerda IH;Pappy A;Ashina S;Robinson CL;Dominguez M;
{Journal}: Curr Pain Headache Rep
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jun 22
{Factor}: 3.904
{DOI}: 10.1007/s11916-024-01271-1
{Abstract}: <B>OBJECTIVE: </B>Chronic headaches are a significant source of disability worldwide. Despite the development of conventional strategies, a subset of patients remain refractory and/or experience side effects following these treatments. Hence, occipital nerve stimulation (ONS) should be considered as an alternative strategy for intractable chronic headaches. This review aims to provide a comprehensive overview of the effectiveness, safety, mechanisms and practical application of ONS for the treatment of headache disorders.<BR><B>RESULTS: </B>Overall response rate of ONS is 35.7-100%, 17-100%, and 63-100% in patients with cluster headache, chronic migraine and occipital neuralgia respectively. Regarding the long-term effectivity in all groups, 41.6-88.0% of patients remain responders after ≥ 18.3 months. The most frequently reported adverse events include lead migration/fracture (13%) and local pain (7.3%). Based on our results, ONS can be considered a safe and effective treatment for chronic intractable headache disorders. To support more widespread application of ONS, additional research with larger sample sizes should be conducted.