PDF(Pubmed)
Abstract：
The aim of this short narrative review was to evaluate the existing literature regarding the clinical use of ketamine among individuals with dementia, especially those with behavioral disturbances. PubMed, Cochrane, and Ovid (Embase, APA PsycINFO, and MEDLINE) databases were searched for abstracts using the search terms \"ketamine\" AND \"dementia.\" Only articles describing the use of ketamine in individuals with dementia were included. Articles that did not include individuals with dementia, did not use ketamine, were published in a non-English language, primarily described animal studies, or were reviews were excluded. Three case reports met the inclusion criteria. One described the use of subcutaneous ketamine for depression, one described the use of intramuscular ketamine for acute agitation, and one described the use of S-ketamine as anesthesia during electroconvulsive therapy for depression and catatonia. No significant adverse effects were reported in any of the cases. Although the use of ketamine in the treatment of depression and agitation associated with dementia has potential, the current evidence remains limited. High-quality prospective studies are needed to confirm the observations of these case reports before ketamine can be used to treat behavioral disturbances in individuals with dementia.
摘要：
这篇简短的叙述性综述的目的是评估现有的关于氯胺酮在痴呆症患者中临床使用的文献。尤其是那些有行为障碍的人。PubMed,科克伦,和奥维德(Embase，APAPsycINFO,和MEDLINE）数据库使用搜索词“氯胺酮”和“痴呆症”搜索摘要。“仅包括描述在痴呆症患者中使用氯胺酮的文章。不包括痴呆症患者的文章，没有使用氯胺酮,以一种非英语语言出版，主要描述了动物研究，或者评论被排除在外。3例病例报告符合纳入标准。一个描述了使用皮下氯胺酮治疗抑郁症，一个人描述了肌内氯胺酮用于急性躁动，和一个描述了使用S-氯胺酮作为麻醉在电惊厥治疗抑郁症和紧张症。在任何情况下均未报告明显的不良反应。尽管使用氯胺酮治疗与痴呆相关的抑郁和躁动具有潜力，目前的证据仍然有限。在氯胺酮可用于治疗痴呆症患者的行为障碍之前，需要高质量的前瞻性研究来确认这些病例报告的观察结果。
