PDF(Pubmed)
Abstract：
BACKGROUND: Long non-coding RNAs (lncRNAs) are abundant and closely related to the occurrence and development of human diseases. LncRNAs are known to play a key role in many cardiovascular diseases. The purpose of this study was to investigate the effect of the RNA component of mitochondrial RNA-processing endoribonuclease (RMRP) on the degree of coronary artery lesions and prognosis in patients with coronary artery disease (CAD).
METHODS: Patients who underwent coronary angiography (CAG) and dynamical-single photon emission computed tomography (D-SPECT) were selected as study subjects, and the results of CAG were reviewed, and the patients were grouped according to SYNTAX score. Evaluate the factors affecting SYNTAX scores. The follow-up analysis was conducted, and the endpoint events were major adverse cardiovascular events (MACEs). Kaplan-Meier method was used to estimate the survival rate, and multivariate Cox regression was used to analyze the relationship between RMRP and MACEs.
RESULTS: The expression level of serum RMRP in patients with CAD was significantly higher than that in healthy people. Multivariate Logistic regression analysis showed that age, low-density lipoprotein cholesterol (LDL-C), RMRP and rest left ventricular ejection fraction (LVEF) were independent factors that affected SYNTAX scores. There were 19 cases of MACEs in the high RMRP group and 9 cases in the low RMRP group, and there was a significant difference in the MACE free survival curve between the two groups. Multivariate Cox regression analysis showed that age, SYNTAX score, rest LVEF and RMRP were risk factors for MACEs.
CONCLUSIONS: Serum RMRP is a key factor affecting the degree of coronary artery disease and prognosis in CAD patients.
METHODS: Patients who underwent coronary angiography (CAG) and dynamical-single photon emission computed tomography (D-SPECT) were selected as study subjects, and the results of CAG were reviewed, and the patients were grouped according to SYNTAX score. Evaluate the factors affecting SYNTAX scores. The follow-up analysis was conducted, and the endpoint events were major adverse cardiovascular events (MACEs). Kaplan-Meier method was used to estimate the survival rate, and multivariate Cox regression was used to analyze the relationship between RMRP and MACEs.
RESULTS: The expression level of serum RMRP in patients with CAD was significantly higher than that in healthy people. Multivariate Logistic regression analysis showed that age, low-density lipoprotein cholesterol (LDL-C), RMRP and rest left ventricular ejection fraction (LVEF) were independent factors that affected SYNTAX scores. There were 19 cases of MACEs in the high RMRP group and 9 cases in the low RMRP group, and there was a significant difference in the MACE free survival curve between the two groups. Multivariate Cox regression analysis showed that age, SYNTAX score, rest LVEF and RMRP were risk factors for MACEs.
CONCLUSIONS: Serum RMRP is a key factor affecting the degree of coronary artery disease and prognosis in CAD patients.
摘要：
背景：长链非编码RNA（lncRNAs）丰富，与人类疾病的发生发展密切相关。已知LncRNAs在许多心血管疾病中起关键作用。目的探讨线粒体RNA加工核糖核酸内切酶(RMRP)的RNA组分对冠心病(CAD)患者冠状动脉病变程度及预后的影响。
方法：选择接受冠状动脉造影（CAG）和动态单光子发射计算机断层扫描（D-SPECT）的患者作为研究对象，并对CAG的结果进行了综述，根据SYNTAX评分对患者进行分组。评估影响SYNTAX分数的因素。进行了后续分析,终点事件为主要不良心血管事件（MACEs）。采用Kaplan-Meier法估计生存率,采用多因素Cox回归分析RMRP与MACEs的关系。
结果：冠心病患者血清RMRP的表达水平明显高于健康人。多因素Logistic回归分析显示,低密度脂蛋白胆固醇（LDL-C），RMRP和静息左心室射血分数（LVEF）是影响SYNTAX评分的独立因素。高RMRP组MACE19例,低RMRP组MACE9例,两组无MACE生存曲线差异有统计学意义。多因素Cox回归分析显示,年龄,SYNTAX评分,休息LVEF和RMRP是MACEs的危险因素.
结论：血清RMRP是影响冠心病患者冠状动脉病变程度及预后的关键因素。
方法：选择接受冠状动脉造影（CAG）和动态单光子发射计算机断层扫描（D-SPECT）的患者作为研究对象，并对CAG的结果进行了综述，根据SYNTAX评分对患者进行分组。评估影响SYNTAX分数的因素。进行了后续分析,终点事件为主要不良心血管事件（MACEs）。采用Kaplan-Meier法估计生存率,采用多因素Cox回归分析RMRP与MACEs的关系。
结果：冠心病患者血清RMRP的表达水平明显高于健康人。多因素Logistic回归分析显示,低密度脂蛋白胆固醇（LDL-C），RMRP和静息左心室射血分数（LVEF）是影响SYNTAX评分的独立因素。高RMRP组MACE19例,低RMRP组MACE9例,两组无MACE生存曲线差异有统计学意义。多因素Cox回归分析显示,年龄,SYNTAX评分,休息LVEF和RMRP是MACEs的危险因素.
结论：血清RMRP是影响冠心病患者冠状动脉病变程度及预后的关键因素。
