{Reference Type}: Journal Article
{Title}: Analysis of long non-coding RNA RMRP in the diagnosis and prognosis of coronary artery disease.
{Author}: Xiao H;Pu J;Jiang G;Pan C;Xu J;Zhang B;Bai M;
{Journal}: J Cardiothorac Surg
{Volume}: 19
{Issue}: 1
{Year}: 2024 Jun 21
{Factor}: 1.522
{DOI}: 10.1186/s13019-024-02870-0
{Abstract}: <B>BACKGROUND: </B>Long non-coding RNAs (lncRNAs) are abundant and closely related to the occurrence and development of human diseases. LncRNAs are known to play a key role in many cardiovascular diseases. The purpose of this study was to investigate the effect of the RNA component of mitochondrial RNA-processing endoribonuclease (RMRP) on the degree of coronary artery lesions and prognosis in patients with coronary artery disease (CAD).<BR><B>METHODS: </B>Patients who underwent coronary angiography (CAG) and dynamical-single photon emission computed tomography (D-SPECT) were selected as study subjects, and the results of CAG were reviewed, and the patients were grouped according to SYNTAX score. Evaluate the factors affecting SYNTAX scores. The follow-up analysis was conducted, and the endpoint events were major adverse cardiovascular events (MACEs). Kaplan-Meier method was used to estimate the survival rate, and multivariate Cox regression was used to analyze the relationship between RMRP and MACEs.<BR><B>RESULTS: </B>The expression level of serum RMRP in patients with CAD was significantly higher than that in healthy people. Multivariate Logistic regression analysis showed that age, low-density lipoprotein cholesterol (LDL-C), RMRP and rest left ventricular ejection fraction (LVEF) were independent factors that affected SYNTAX scores. There were 19 cases of MACEs in the high RMRP group and 9 cases in the low RMRP group, and there was a significant difference in the MACE free survival curve between the two groups. Multivariate Cox regression analysis showed that age, SYNTAX score, rest LVEF and RMRP were risk factors for MACEs.<BR><B>CONCLUSIONS: </B>Serum RMRP is a key factor affecting the degree of coronary artery disease and prognosis in CAD patients.