PDF(Pubmed)
Abstract：
The link between celiac disease (CeD) and thyroid dysfunction has been investigated. However, it is uncertain if CeD is causally linked to thyroid dysfunction. A 2-sample Mendelian randomization study was conducted to ascertain the causal connection between CeD and thyroid dysfunction. Using data from the FinnGen Consortium, a 2-sample Mendelian randomization study was conducted to look at the connection between thyroid dysfunction and CeD. Another replication of the data from the UK Biobank was subsequently performed to confirm our findings. Furthermore, a sequence of sensitivity analyses was performed. The inverse variance weighting technique demonstrates that genetically determined CeD is substantially linked with hypothyroidism, thyrotoxicosis, Graves\' disease, and free thyroxine. However, no significant associations were found between CeD and thyroid-stimulating hormone or thyroiditis. Moreover, we achieve the same results in duplicate datasets, which increases the reliability of our findings. This study suggests that CeD and thyroid dysfunction are linked, and it gives theoretical support and new ways of thinking about how to diagnose and treat both conditions.
摘要：
已经研究了乳糜泻（CeD）与甲状腺功能障碍之间的联系。然而,目前尚不确定CeD是否与甲状腺功能障碍有因果关系.进行了2个样本的孟德尔随机研究，以确定CeD与甲状腺功能障碍之间的因果关系。使用FinnGen联盟的数据，我们进行了一项2个样本的孟德尔随机研究,以研究甲状腺功能异常与CeD之间的联系.随后对来自英国生物库的数据进行了另一次复制，以证实我们的发现。此外，我们进行了一系列的敏感性分析.逆方差加权技术表明，遗传确定的CeD与甲状腺功能减退症有关，甲状腺毒症,严重的疾病，和游离甲状腺素.然而,未发现CeD与促甲状腺激素或甲状腺炎之间存在显著关联.此外，我们在重复的数据集中实现相同的结果，这增加了我们发现的可靠性。这项研究表明，CeD和甲状腺功能障碍是有联系的，它为如何诊断和治疗这两种疾病提供了理论支持和新的思维方式。
