Abstract：
The role of the cerebellum in amnestic mild cognitive impairment (aMCI), typically a prodromal stage of Alzheimer\'s disease, is not fully understood. We studied the lobule-specific cerebello-cerebral connectivity in 15 cognitively normal and 16 aMCI using resting-state functional MRI. Our analysis revealed weaker connectivity between the cognitive cerebellar lobules and parietal lobe in aMCI. However, stronger connectivity was observed in the cognitive cerebellar lobules with certain brain regions, including the precuneus cortex, posterior cingulate gyrus, and caudate nucleus in participants with worse cognition. Leveraging these measurable changes in cerebello-parietal functional networks in aMCI could offer avenues for future therapeutic interventions.
摘要：
小脑在遗忘型轻度认知障碍（aMCI）中的作用，通常是阿尔茨海默病的前驱阶段，没有完全理解。我们使用静息状态功能MRI研究了15种认知正常和16种aMCI的小叶特异性小脑-脑连通性。我们的分析显示，aMCI中认知小脑小叶和顶叶之间的连通性较弱。然而,在具有某些大脑区域的认知小脑小叶中观察到更强的连通性，包括前脑皮层,后扣带回，认知较差的参与者的尾状核。利用aMCI中小脑-顶叶功能网络的这些可测量的变化可以为未来的治疗干预提供途径。
