关键词: applications immunotherapy perspectives radiotherapy tumor organoids

Mesh : Organoids / radiation effects pathology Humans Neoplasms / radiotherapy pathology Radiobiology / methods Animals

来  源:   DOI:10.3892/or.2024.8759

Abstract:
Radiotherapy exhibits significant versatility and efficacy in cancer treatment, thereby playing a crucial role in the field of oncology. However, there remains an urgent need for extensive research on various aspects of radiotherapy, including target selection, damage repair and its combination with immunotherapy. Particularly, the development of in vitro models to replicate in vivo tumor lesion responses is vital. The present study provides a thorough review of the establishment and application of tumor organoids in radiotherapy, aiming to explore their potential impact on cancer treatment.
摘要:
放射治疗在癌症治疗中具有显著的通用性和有效性,从而在肿瘤学领域发挥着至关重要的作用。然而,仍然迫切需要对放射治疗的各个方面进行广泛的研究,包括目标选择,损伤修复及其与免疫治疗的结合。特别是,体外模型的发展,以复制体内肿瘤病变的反应是至关重要的。本研究对肿瘤类器官在放射治疗中的建立和应用进行了全面综述。旨在探索它们对癌症治疗的潜在影响。
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