Abstract：
Radiotherapy is a pivotal means of cancer treatment, but it often leads to radiation dermatitis, a skin injury caused by radiation-induced excess reactive oxygen species (ROS). Scavenging free radicals in the course of radiation therapy will be an effective means to prevent radiation dermatitis. This study demonstrates a novel double network hydrogel doped with MoS2 nanosheets for the prevention of radiation-induced dermatitis. The resultant SPM hydrogel constructed from polyacrylamide (PAM) and sodium alginate (SA) nanofiber presented favorable mechanical and adhesion properties. It could conform well to the human body\'s irregular contours without secondary dressing fixation, making it suitable for skin protection applications. The in vitro and in vivo experiments showed that the antioxidant properties conferred by MoS2 nanosheets enable SPM to effectively mitigate excessive ROS and reduce oxidative stress, thereby preventing radiation dermatitis caused by oxidative damage. Biosafety assessments indicated good biocompatibility of the composite hydrogel, suggesting SPM\'s practicality and potential as an external dressing for skin radiation protection.
摘要：
放射治疗是癌症治疗的关键手段,但它经常导致放射性皮炎，由辐射诱导的过量活性氧（ROS）引起的皮肤损伤。在放射治疗过程中清除自由基将是预防放射性皮炎的有效手段。这项研究证明了一种新型的掺杂有MoS2纳米片的双网络水凝胶，用于预防辐射诱发的皮炎。由聚丙烯酰胺（PAM）和海藻酸钠（SA）纳米纤维构成的SPM水凝胶具有良好的机械性能和粘合性能。它可以很好地符合人体的不规则轮廓，无需二次敷料固定，使其适用于皮肤保护应用。体外和体内实验表明，MoS2纳米片赋予的抗氧化特性使SPM能够有效减轻过量的ROS并减少氧化应激，从而防止氧化损伤引起的放射性皮炎。生物安全性评估表明复合水凝胶具有良好的生物相容性，表明SPM作为皮肤辐射防护外用敷料的实用性和潜力。
