PDF(Pubmed)
Abstract：
The World Health Organization (WHO) recommends exclusive breastfeeding for the first 6 months of life followed by complementary foods and sustained breastfeeding for at least 2 years, underscoring its pivotal role in reducing infant mortality and preventing various illnesses. This perspective delves into the intricate relationship between breastfeeding practices, early life antibiotic exposure, and infant gut microbiome development, highlighting their profound influence on child health outcomes. Antibiotics are extensively prescribed during pregnancy and childhood, disrupting the microbiome, and are related to increased risks of allergies, obesity, and neurodevelopmental disorders. Breastfeeding is a significant determinant of a healthier gut microbiome, characterized by higher levels of beneficial bacteria such as Bifidobacterium and lower levels of potential pathogens. Despite widespread recognition of the benefits of breastfeeding, gaps persist in healthcare practices and support mechanisms, exacerbating challenges faced by breastfeeding families. This highlights the pressing need for comprehensive research encompassing breastfeeding behaviors, human milk intake, and their impact on infant health outcomes. Additionally, promoting awareness among healthcare providers and families regarding the detrimental effects of unnecessary formula supplementation could facilitate informed decision-making and bolster exclusive breastfeeding rates. Moreover, donor human milk (DHM) is a promising alternative to formula, potentially mitigating disruptions to the infant gut microbiome after antibiotic exposure. Overall, prioritizing breastfeeding support interventions and bridging research gaps are essential steps towards improving child health outcomes on a global scale.
摘要：
世界卫生组织（WHO）建议在生命的头6个月进行纯母乳喂养，然后补充食物和持续母乳喂养至少2年。强调其在降低婴儿死亡率和预防各种疾病方面的关键作用。这种观点深入研究了母乳喂养实践之间的复杂关系，早期抗生素暴露，和婴儿肠道微生物组发育，强调它们对儿童健康结果的深远影响。在怀孕和童年期间广泛使用抗生素，破坏微生物组，并且与过敏风险增加有关，肥胖，和神经发育障碍。母乳喂养是更健康的肠道微生物组的重要决定因素，其特征在于更高水平的有益菌如双歧杆菌和更低水平的潜在病原体。尽管人们普遍认识到母乳喂养的好处，医疗保健实践和支持机制方面仍然存在差距，这加剧了母乳喂养家庭面临的挑战。这凸显了对包括母乳喂养行为在内的全面研究的迫切需要，人乳摄入量，以及它们对婴儿健康结果的影响。此外,提高医疗保健提供者和家庭对不必要配方奶粉补充的有害影响的认识可以促进知情决策并提高纯母乳喂养率.此外，供体人乳（DHM）是一种有前途的替代配方，可能减轻抗生素暴露后对婴儿肠道微生物组的破坏。总的来说,优先考虑母乳喂养支持干预措施和弥合研究差距是在全球范围内改善儿童健康结果的重要步骤。
