PDF(Pubmed)
Abstract：
Folliculitis decalvans (FD) is a rare type of inflammatory scalp disorder that leads to scarring alopecia. It is classified as primary neutrophilic cicatricial alopecia. FD presents a challenging scenario in clinical dermatology due to its rarity, resistance to treatment, and potential for scarring alopecia. This inflammatory scalp disorder primarily affects middle-aged adults, predominantly males. While its exact pathogenesis remains uncertain, a deficient host immune response to Staphylococcus aureus infection is hypothesized. Therapeutic interventions for FD pose difficulties, with limited treatment options available A 58-year-old female patient presented with a history of follicular papules that gradually progressed to form clusters of pustules, crusting, and hemorrhagic lesions with tufting of hairs on the crown area of the scalp, and was diagnosed with FD. Considering isotretinoin\'s role in inhibiting abnormal keratinization and inflammation, and rifampicin\'s ability to eradicate S. aureus, the combination of both provides a comprehensive approach to tackling the underlying factors contributing to FD. Despite previous unsuccessful treatments, combination therapy with isotretinoin and rifampicin yielded a remarkable outcome, prompting further exploration of this approach.
摘要：
性毛囊炎（FD）是一种罕见的炎症性头皮疾病，可导致瘢痕性脱发。它被归类为原发性嗜中性粒细胞性瘢痕性脱发。FD由于其稀有性，在临床皮肤病学中提出了一个具有挑战性的方案，抵抗治疗,并有可能形成脱发的疤痕.这种炎症性头皮疾病主要影响中年人，主要是男性。虽然其确切的发病机制仍不确定，假设宿主对金黄色葡萄球菌感染的免疫反应不足.FD的治疗干预造成困难，一位58岁的女性患者，有滤泡丘疹病史，逐渐发展形成脓疱，结壳,和出血性病变，在头皮的冠部区域簇绒毛发，并被诊断为FD。考虑到异维A酸在抑制异常角质化和炎症中的作用，和利福平根除金黄色葡萄球菌的能力，两者的结合提供了一个全面的方法来解决导致FD的潜在因素。尽管以前的治疗不成功，异维A酸和利福平联合治疗产生了显著的结果，促使人们进一步探索这种方法。
