PDF(Pubmed)
Abstract：
Microplastic (MP) pollution is a growing global concern because of its potential to impair human health, particularly with regard to fetal development. However, the origins of prenatal MP exposure and its effects on fetal development have not been well studied. This study aimed to provide a systematic review of the literature regarding the impact of microplastics on pregnancy and fetal development. PubMed, Embase, ScienceDirect, Web of Science, Scopus, and Google Scholar were searched from 2010 until March 2024. Original publications exploring the impact of microplastics on pregnancy and fetal development were included in the study. After selecting papers, two independent reviewers extracted data regarding study characteristics, microplastics identified, and reproductive impacts. The quality of studies was assessed using the Critical Appraisal Checklists for Studies created by the Joanna Briggs Institute (JBI). Twelve studies, including 234 subjects, were selected from a total of 2,809 citations for the final qualitative analysis. Articles were published between 2021 and 2024, and most were conducted in China. The results of the included studies confirmed the existence of microplastics with varying sizes (2.1 to 100 micrometers) in the placenta and the fetal body. Studies revealed correlations between lifestyle choices and the presence of microplastics in the placenta. They also reported correlations between the level of microplastics and diminished microbiome diversity, reduced birthweights, affected gestational age, and fetal growth and development. Microplastics may be detrimental to a developing fetus during pregnancy. Nonetheless, more thorough research is required to comprehend the impact of microplastic exposure on pregnancy and fetal development.
摘要：
微塑料（MP）污染因其可能损害人类健康而日益受到全球关注，特别是在胎儿发育方面。然而,产前MP暴露的起源及其对胎儿发育的影响尚未得到很好的研究。本研究旨在对有关微塑料对妊娠和胎儿发育影响的文献进行系统综述。PubMed,Embase,ScienceDirect,WebofScience,Scopus,和谷歌学者从2010年到2024年3月被搜索。研究中包括了探索微塑料对妊娠和胎儿发育影响的原始出版物。选择论文后，两名独立审稿人提取了有关研究特征的数据，微塑料鉴定，和生殖影响。使用JoannaBriggs研究所（JBI）创建的关键评估清单评估研究质量。12项研究,包括234个科目，从总共2,809篇引文中选择进行最后的定性分析。文章发表于2021年至2024年之间，大部分在中国进行。纳入研究的结果证实了胎盘和胎儿体内存在不同尺寸（2.1至100微米）的微塑料。研究揭示了生活方式选择与胎盘中微塑料的存在之间的相关性。他们还报告了微塑料水平与微生物组多样性减少之间的相关性，减少出生体重，受影响的胎龄，和胎儿的生长发育。微塑料可能对怀孕期间发育中的胎儿有害。尽管如此，需要更深入的研究来了解微塑料暴露对怀孕和胎儿发育的影响。
