PDF(Pubmed)
Abstract：
Mal De Meleda is a rare genetic disorder characterized by palmoplantar keratoderma, often presenting challenges in diagnosis and management. This case report discusses an 18-year-old male presenting with thickened, yellowish skin on both palms and soles, accompanied by itching and cracking. A diagnosis of the transgradiens variant of Mal De Meleda was established through clinical and histopathological examination. Treatment with oral acitretin and topical moisturizers resulted in significant improvement. This report highlights the importance of recognizing rare variants of palmoplantar keratoderma and the need for a multidisciplinary approach to diagnosis and management.
摘要：
MalDeMeleda是一种罕见的遗传性疾病，其特征是掌plant角化症，经常在诊断和管理方面提出挑战。此病例报告讨论了一名18岁男性，表现为增厚，手掌和脚底都有淡黄色的皮肤，伴有瘙痒和开裂。通过临床和组织病理学检查确定了MalDeMeleda的移行变体的诊断。口服阿维A和局部保湿剂的治疗导致了显著的改善。本报告强调了识别掌plant角化病的罕见变异的重要性，以及对诊断和管理的多学科方法的需求。
