%0 Case Reports
%T Transgradient Variant of Mal De Meleda Presenting As Palmoplantar Keratoderma: A Case Report.
%A Khan A
%A Singh A
%A Madke B
%A Gupta K
%A Sree Ramya T
%J Cureus
%V 16
%N 5
%D 2024 May
%M 38903266
暂无%R 10.7759/cureus.60717
%X Mal De Meleda is a rare genetic disorder characterized by palmoplantar keratoderma, often presenting challenges in diagnosis and management. This case report discusses an 18-year-old male presenting with thickened, yellowish skin on both palms and soles, accompanied by itching and cracking. A diagnosis of the transgradiens variant of Mal De Meleda was established through clinical and histopathological examination. Treatment with oral acitretin and topical moisturizers resulted in significant improvement. This report highlights the importance of recognizing rare variants of palmoplantar keratoderma and the need for a multidisciplinary approach to diagnosis and management.