PDF(Pubmed)
Abstract：
Current brain tumor treatments are limited by the skull and BBB, leading to poor prognosis and short survival for glioma patients. We introduce a novel minimally-invasive brain tumor suppression (MIBTS) device combining personalized intracranial electric field therapy with in-situ chemotherapeutic coating. The core of our MIBTS technique is a wireless-ultrasound-powered, chip-sized, lightweight device with all functional circuits encapsulated in a small but efficient \"Swiss-roll\" structure, guaranteeing enhanced energy conversion while requiring tiny implantation windows ( ~ 3 × 5 mm), which favors broad consumers acceptance and easy-to-use of the device. Compared with existing technologies, competitive advantages in terms of tumor suppressive efficacy and therapeutic resolution were noticed, with maximum ~80% higher suppression effect than first-line chemotherapy and 50-70% higher than the most advanced tumor treating field technology. In addition, patient-personalized therapy strategies could be tuned from the MIBTS without increasing size or adding circuits on the integrated chip, ensuring the optimal therapeutic effect and avoid tumor resistance. These groundbreaking achievements of MIBTS offer new hope for controlling tumor recurrence and extending patient survival.
摘要：
目前脑肿瘤的治疗受到颅骨和血脑屏障的限制，导致胶质瘤患者预后差，生存期短。我们介绍了一种新型的微创脑肿瘤抑制（MIBTS）装置，该装置将个性化颅内电场治疗与原位化疗涂层相结合。我们的MIBTS技术的核心是无线超声供电，芯片尺寸,所有功能电路封装在一个小型但高效的“瑞士卷”结构中的轻质设备，保证增强的能量转换，同时需要微小的植入窗口（〜3×5毫米），这有利于广大消费者接受和易于使用的设备。与现有技术相比,在肿瘤抑制疗效和治疗分辨率方面的竞争优势被注意到，抑制效果最高比一线化疗高80％，比最先进的肿瘤治疗领域技术高50-70％。此外,患者个性化治疗策略可以从MIBTS进行调整，而无需增加尺寸或在集成芯片上添加电路，确保最佳治疗效果，避免肿瘤耐药。MIBTS的这些突破性成就为控制肿瘤复发和延长患者生存期提供了新的希望。
