Abstract：
Ghost cell odontogenic carcinoma (GCOC) is defined as a rare type of odontogenic carcinoma that is characterized by ghost cells and occasional dentinoid. However, the current classification system based primarily on the presence of ghost cells has limitations in the diagnosis of GCOC and its histologic mimics including odontogenic carcinoma with dentinoid (OCD). This study reviewed previous studies on β-catenin nuclear translocation and WNT pathway mutations in GCOC and OCD and discussed the potential utility of a new molecular-based classification \"WNT pathway-altered malignant odontogenic tumor\" for these rare odontogenic tumors.
摘要：
鬼细胞牙源性癌（GCOC）被定义为一种罕见类型的牙源性癌，其特征是鬼细胞和偶发的类牙本质。然而,目前主要基于鬼细胞存在的分类系统在GCOC及其组织学模拟物(包括牙源性牙样癌(OCD))的诊断方面存在局限性.本研究回顾了先前关于GCOC和OCD中β-catenin核易位和WNT途径突变的研究，并讨论了新的基于分子的分类“WNT途径改变的恶性牙源性肿瘤”对这些罕见牙源性肿瘤的潜在用途。
