Mesh : Humans Mutation Cyclin-Dependent Kinase Inhibitor p16 / genetics Cyclin-Dependent Kinase 4 / genetics Female Skin Neoplasms / genetics pathology drug therapy Middle Aged Adenocarcinoma / genetics drug therapy pathology Protein Kinase Inhibitors / therapeutic use Cyclin-Dependent Kinase 6 / genetics antagonists & inhibitors Male Pyridines / therapeutic use Sweat Gland Neoplasms / genetics pathology drug therapy Piperazines / therapeutic use

来  源:   DOI:10.46883/2024.25921022

Abstract:
Spiradenocarcinomas are rare malignant skin adnexal tumors. We describe a novel case of a patient with an aggressive CDKN2A-mutated spiradenocarcinoma who responded to a CDK4/6 inhibitor. This case highlights the unique nature of spiradenocarcinomas as well as the potential benefit of targeted therapy.
摘要:
螺旋腺癌是罕见的恶性皮肤附件肿瘤。我们描述了一个新的病例,患有侵袭性CDKN2A突变的螺旋腺癌,对CDK4/6抑制剂有反应。该病例突出了螺旋腺癌的独特性质以及靶向治疗的潜在益处。
公众号