PDF(Pubmed)
Abstract：
Aim: To investigate the impact of human herpes virus (HHV) carriage on lung microbiota, and its correlation with clinical features and laboratory indicators in patients.Methods: Retrospective analysis was conducted on 30 outpatient lung infection cases, which were divided into HHV (n = 15) and non-HHV (n = 15) groups. mNGS detected microbial composition. Microbial diversity and abundance were tested using Shannon and Chao1 indices. Their relationship with laboratory indicators were explored.Results: Significant differences in microbial abundance and distribution were found between two groups (p < 0.05). Moreover, HHV group showed negative correlations (p < 0.05) between Prevotella, Porphyromonas, Streptococcus and basophil/eosinophil percentages.Conclusion: HHV carriage impacts lung microbiota, emphasizing the need for clinicians to pay attention to HHV reactivation in outpatient lung infection patients.
This study looked at how a common virus called human herpesvirus (HHV) affects the bacteria in our lungs. We wanted to see if HHV is linked to how sick we feel and what tests show. We split 30 people who had lung infections into two groups – 15 with HHV and 15 without – and checked how sick they felt, did some tests, and looked at the types of bacteria in their lungs. Both groups felt similarly sick and got better with medicine, but people with HHV had fewer of a certain type of blood cell. People with and without HHV also had different types of bacteria in their lungs. This study helps us understand why people get sick with lung infections and how to make them better. It might also help doctors decide how to treat people with lung infections.
This study looked at how a common virus called human herpesvirus (HHV) affects the bacteria in our lungs. We wanted to see if HHV is linked to how sick we feel and what tests show. We split 30 people who had lung infections into two groups – 15 with HHV and 15 without – and checked how sick they felt, did some tests, and looked at the types of bacteria in their lungs. Both groups felt similarly sick and got better with medicine, but people with HHV had fewer of a certain type of blood cell. People with and without HHV also had different types of bacteria in their lungs. This study helps us understand why people get sick with lung infections and how to make them better. It might also help doctors decide how to treat people with lung infections.
摘要：
目的:探讨人类疱疹病毒(HHV)携带对肺部微生物群的影响,及其与患者临床特征和实验室指标的相关性。方法:对30例门诊肺部感染病例进行回顾性分析,分为HHV组(n=15)和非HHV组(n=15)。mNGS检测到微生物组成。使用Shannon和Chao1指数测试了微生物的多样性和丰度。探讨了它们与实验室指标的关系。结果:两组微生物丰度和分布差异有统计学意义(p<0.05)。此外，HHV组与Prevotella之间呈负相关（p<0.05），卟啉单胞菌,链球菌和嗜碱性粒细胞/嗜酸性粒细胞百分比。结论：HHV携带会影响肺部菌群，强调临床医生需要重视门诊肺部感染患者的HHV再激活。
这项研究研究了一种称为人类疱疹病毒（HHV）的常见病毒如何影响我们肺部的细菌。我们想看看HHV是否与我们的病态和测试表明有关。我们将30名肺部感染的人分成两组，15名患有HHV的人和15名没有HHV的人，并检查了他们的病情，做了一些测试,观察他们肺部的细菌类型。两组都感到同样的不适，药物治疗好转，但是患有HHV的人有较少的某种类型的血细胞。有和没有HHV的人在他们的肺部也有不同类型的细菌。这项研究帮助我们理解为什么人们会因肺部感染而生病，以及如何使他们变得更好。它还可以帮助医生决定如何治疗肺部感染患者。
这项研究研究了一种称为人类疱疹病毒（HHV）的常见病毒如何影响我们肺部的细菌。我们想看看HHV是否与我们的病态和测试表明有关。我们将30名肺部感染的人分成两组，15名患有HHV的人和15名没有HHV的人，并检查了他们的病情，做了一些测试,观察他们肺部的细菌类型。两组都感到同样的不适，药物治疗好转，但是患有HHV的人有较少的某种类型的血细胞。有和没有HHV的人在他们的肺部也有不同类型的细菌。这项研究帮助我们理解为什么人们会因肺部感染而生病，以及如何使他们变得更好。它还可以帮助医生决定如何治疗肺部感染患者。
