PDF(Pubmed)
Abstract：
A growing body of evidence indicates the existence of abnormal local and long-range functional connection patterns in patients with alcohol use disorder (AUD). However, it has yet to be established whether AUD is associated with abnormal interhemispheric and intrahemispheric functional connection patterns. In the present study, we analysed resting-state functional magnetic resonance imaging data from 55 individuals with AUD and 32 healthy nonalcohol users. For each subject, whole-brain functional connectivity density (FCD) was decomposed into ipsilateral and contralateral parts. Correlation analysis was performed between abnormal FCD and a range of clinical measurements in the AUD group. Compared with healthy controls, the AUD group exhibited a reduced global FCD in the anterior and middle cingulate gyri, prefrontal cortex and thalamus, along with an enhanced global FCD in the temporal, parietal and occipital cortices. Abnormal interhemispheric and intrahemispheric FCD patterns were also detected in the AUD group. Furthermore, abnormal global, contralateral and ipsilateral FCD data were correlated with the mean amount of pure alcohol and the severity of alcohol addiction in the AUD group. Collectively, our findings indicate that global, interhemispheric and intrahemispheric FCD may represent a robust method to detect abnormal functional connection patterns in AUD; this may help us to identify the neural substrates and therapeutic targets of AUD.
摘要：
越来越多的证据表明，酒精使用障碍（AUD）患者存在异常的局部和远程功能连接模式。然而,尚未确定AUD是否与异常的半球间和半球内功能连接模式相关。在本研究中,我们分析了55名AUD患者和32名健康非酒精患者的静息态功能磁共振成像数据.对于每个主题，全脑功能连接密度(FCD)分解为同侧和对侧.在AUD组中异常FCD与一系列临床测量之间进行相关性分析。与健康对照相比，AUD组显示前扣带回和中扣带回的整体FCD减少，前额叶皮质和丘脑,随着时间上增强的全球FCD，顶骨和枕骨皮质。在AUD组中还检测到异常的半球间和半球内FCD模式。此外，全球异常，在AUD组中,对侧和同侧FCD数据与纯酒精的平均用量和酒精成瘾的严重程度相关.总的来说，我们的研究结果表明，全球，半球间和半球内FCD可能代表了一种检测AUD异常功能连接模式的可靠方法;这可能有助于我们识别AUD的神经基质和治疗靶标。
