关键词: complications covid-19 long covid syndrome persistent symptoms post covid syndrome sequelae

来  源:   DOI:10.7759/cureus.60652   PDF(Pubmed)

Abstract:
BACKGROUND: The long COVID phase is characterized by signs and symptoms persisting for at least three months after recovery from acute COVID-19 illness. There is limited data on comprehensive long-term clinical follow-up of COVID-19 patients.
OBJECTIVE: This study aims to explore the burden and symptomatology of long COVID syndrome and its association with various health parameters.
METHODS: This prospective observational study was conducted in Delhi from May 2022 to March 2023.
METHODS: A total of 553 adult patients who had recovered from COVID-19 were enrolled in the study. A sociodemographic and clinical profile was obtained using validated questionnaires, along with an evaluation of biochemical parameters to assess the associated factors.
METHODS: Chi-square test, unpaired t-test, and bivariate regression analysis were applied using Statistical Product and Service Solutions (SPSS, version 28; IBM SPSS Statistics for Windows, Armonk, NY). A p value of <0.05 was considered significant.
RESULTS: A total of 252 patients (45.6%) had long COVID syndrome, which was significantly associated with the presence of any pre-existing comorbidity (OR=1.46 (1.02-2.09); p=0.039), previous history of hypertension (OR=1.82 (1.07-3.09); p=0.027), and vaccination against COVID-19 (OR=1.392 (1.171-1.656); p=0.003). The most common symptoms reported were persistent fatigue (33.3%) and persistent dry cough (28.5%). Patients with long COVID syndrome are also reported to have poorer sleep quality. Biochemical findings showed abnormal T lymphocytes (9.3%) and raised HbA1c (11.9%).
CONCLUSIONS: Multiple risk factors and symptoms associated with long COVID syndrome were identified in this study. Research efforts and knowledge regarding the pattern of illness will aid in long-term monitoring and development of interventional strategies and guidelines for the care of recovered COVID-19 patients.
摘要:
背景:长期COVID阶段的特征是在急性COVID-19疾病恢复后,体征和症状持续至少三个月。关于COVID-19患者的综合长期临床随访数据有限。
目的:本研究旨在探讨长COVID综合征的负担和症状及其与各种健康参数的关系。
方法:这项前瞻性观察性研究于2022年5月至2023年3月在德里进行。
方法:共有553名从COVID-19中康复的成年患者被纳入研究。使用经过验证的问卷获得了社会人口统计学和临床概况,以及对生化参数的评估,以评估相关因素。
方法:卡方检验,不成对t检验,使用统计产品和服务解决方案(SPSS,版本28;IBMSPSSStatisticsforWindows,Armonk,NY).<0.05的p值被认为是显著的。
结果:共有252例患者(45.6%)患有长型COVID综合征,这与任何先前存在的合并症的存在显着相关(OR=1.46(1.02-2.09);p=0.039),既往高血压病史(OR=1.82(1.07-3.09);p=0.027),和COVID-19疫苗接种(OR=1.392(1.171-1.656);p=0.003)。报告的最常见症状是持续疲劳(33.3%)和持续干咳(28.5%)。据报道,患有长期COVID综合征的患者的睡眠质量也较差。生化检查显示T淋巴细胞异常(9.3%)和HbA1c升高(11.9%)。
结论:这项研究发现了与长COVID综合征相关的多种危险因素和症状。有关疾病模式的研究工作和知识将有助于长期监测和制定康复COVID-19患者的干预策略和指南。
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