UNASSIGNED: In a prospective, multicentric observational study, a selection of uremic toxin levels of children (aged 0-18 years) with CKD stage 1 to 5D was assessed every 3 months (maximum 2 years) along with clinical growth parameters. Linear mixed models with a random slope for age and a random intercept for child were fitted for height (in cm and SD scores [SDS]). A piecewise linear association between age and height was assumed.
UNASSIGNED: Data analysis included data from 560 visits of 81 children (median age 9.4 years; 2/3 male). In (pre)school aged children (aged 2-12 years), a 10% increase in concurrent indoxyl sulfate (IxS, total) concentration resulted in an estimated mean height velocity decrease of 0.002 SDS/yr (P < 0.05), given that CKD stage, growth hormone (GH), bicarbonate concentration, and dietary protein intake were held constant. No significant association with height velocity was found in children during pubertal stages (aged >12 years).
UNASSIGNED: The present study demonstrated that, especially IxS contributes to a lower height velocity in (pre)school children, whereas we could not find a role for uremic toxins with height velocity during pubertal stages.
■在未来,多中心观察研究,我们每3个月(最长2年)对CKD1~5D期儿童(0~18岁)的尿毒症毒素水平以及临床生长参数进行了选择评估.对于身高(cm和SD评分[SDS]),拟合了具有年龄随机斜率和儿童随机截距的线性混合模型。假设年龄和身高之间存在分段线性关联。
数据分析包括81名儿童(平均年龄9.4岁;2/3男性)的560次访视数据。(学前)儿童(2-12岁),并发硫酸吲哚酚增加10%(IXS,总)浓度导致估计的平均高度速度降低0.002SDS/yr(P<0.05),考虑到CKD阶段,生长激素(GH),碳酸氢盐浓度,和膳食蛋白质摄入量保持恒定。在青春期(年龄>12岁)的儿童中,没有发现与身高速度的显着关联。
■本研究表明,尤其是IxS有助于降低(学前)儿童的身高速度,而在青春期阶段,我们找不到尿毒症毒素对身高速度的作用。